Chemical and Genetic Zebrafish Models to Define Mechanisms of and Treatments for Dopaminergic Neurodegeneration

Details

• Personal Author:
  Freeman JL ; Wasel O
• Description:
  The zebrafish (Danio rerio) is routinely used in biological studies as a vertebrate model system that provides unique strengths allowing applications in studies of neurodevelopmental and neurodegenerative diseases. One specific advantage is that the neurotransmitter systems are highly conserved throughout vertebrate evolution, including between zebrafish and humans. Disruption of the dopaminergic signaling pathway is linked to multiple neurological disorders. One of the most common is Parkinson's disease, a neurodegenerative disease associated with the loss of dopaminergic neurons, among other neuropathological characteristics. In this review, the development of the zebrafish's dopaminergic system, focusing on genetic control of the dopaminergic system, is detailed. Second, neurotoxicant models used to study dopaminergic neuronal loss, including 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the pesticides paraquat and rotenone, and 6-hydroxydopamine (6-OHDA), are described. Next, zebrafish genetic knockdown models of dj1, pink1, and prkn established for investigating mechanisms of Parkinson's disease are discussed. Chemical modulators of the dopaminergic system are also highlighted to showcase the applicability of the zebrafish to identify mechanisms and treatments for neurodegenerative diseases such as Parkinson's disease associated with the dopaminergic system. [Description provided by NIOSH]
• Subjects:
  Animals Genetics Nervous System Nervous System Diseases Occupational Health Safety
• Keywords:
  Analytical Models Animal Studies Author Keywords: Dj1 Brain Function Brain Matter Chemical Indicators Chemicals Dopamine Genetic Factors Hydroxy Compounds Models MPTP Neurological Diseases Neurological Disorders Neurological Reactions Neurological System Neuropathology Neurotoxicity Neurotoxins Neurotransmission Neurotransmitters Paraquat Parkinsons Disease Pink1 Prkn Rotenone Zebrafish

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• ISSN:
  1422-0067
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Indiana ; Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  21
• Issue:
  17
• NIOSHTIC Number:
  nn:20060706
• Citation:
  Int J Mol Sci 2020 Aug; 21(17):5981
• Contact Point Address:
  Jennifer L. Freeman, School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
• Email:
  jfreema@purdue.edu
• CAS Registry Number:
  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (CAS RN 28289-54-5) ; 6-Hydroxydopamine (CAS RN 1199-18-4) ; Dopamine (CAS RN 51-61-6) ; Methyl viologen (CAS RN 1910-42-5) ; Rotenone (CAS RN 83-79-4)
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  International Journal of Molecular Sciences
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d1089c3b8170342664abfbf98339e0bda3771cce2f47eeea1a5a32708e0cdd76ee38a37f15c8cc67883f3faec52cd1f1aafbe34b9ee2d1498d622a2504dc7f6b
• Download URL:
  https://stacks.cdc.gov/view/cdc/224539/cdc_224539_DS1.pdf
• File Type:
  [PDF - 600.81 KB ]