Comparison of Cobalt and Chromium Binding to Blood Elements

Details

• Personal Author:
  Karol MH ; Venezia C
• Description:
  Macromolecular binding of metals is thought to be a prerequisite for induction of metal sensitivity. In this study, the binding of cobalt(II) to blood components was investigated. Incubation of 60Co with blood yielded a mean erythrocyte binding of 10.3 × 107 Co atoms/cell. Incubation of the metal with serum resulted in binding of 8.3 × 10-9 mol Co/mg protein. A comparison was made with analogous binding of chromium(III), a metal recognized for its sensitizing potency. Binding of chromium to proteins and blood cells was 20-fold higher than that obtained with cobalt. With both metals, binding to serum proteins was non-specific. The greater binding by chromium, when compared with cobalt, is consistent with the greater sensitizing ability of this metal. [Description provided by NIOSH]
• Subjects:
  Blood Chromium Metals Occupational Health Safety
• Keywords:
  Author Keywords: Macromolecular-metal Binding Biological Effects Cobalt Cobalt Sensitivity Metal-erytrocyte Binding Metal Sensitivity Protein-metal Interactions Proteins Sensitivity Testing
• ISSN:
  0300-483X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  125-133
• Volume:
  30
• Issue:
  2
• NIOSHTIC Number:
  nn:20060668
• Citation:
  Toxicology 1984 Mar; 30(2):125-133
• Contact Point Address:
  Meryl H. Karol, Department of Industrial, Environmental Health Sciences, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261 U.S.A.
• CAS Registry Number:
  16065-83-1 ; Cobalt (CAS RN 7440-48-4)
• Federal Fiscal Year:
  1984
• Performing Organization:
  University of Pittsburgh
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology
• End Date:
  19830430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f4d4af2d1a11ccbc162f59dc316efb5ef2018b45d8b7cd9427d339cf26049719733c700667358f29c9cfa939978b4ea98dadeea754749460dc67f90e12ac9294
• Download URL:
  https://stacks.cdc.gov/view/cdc/224511/cdc_224511_DS1.pdf
• File Type:
  [PDF - 461.39 KB ]