Effects of Aging on Hepatic and Pulmonary Glutathione S-Transferase Activities in Male and Female Fischer 344 Rats

Details

• Personal Author:
  Leibman KC ; Spearman ME
• Description:
  The effects of aging on cytosolic glutathione S-transferase activities were evaluated with liver and lung cytosol from male and female Fischer 344 rats 3, 12, and 24 months of age. Age-related changes were tissue-, sex-, and substrate-specific. With liver and lung cytosol from both males and females, rates of metabolism of 1,2-epoxy-3-(p-nitrophenoxy)propane and p-nitrobenzyl chloride were lower in the old group than in the young group; however, patterns of decrease differed with tissue and sex. With 1,2-dichloro-4-nitrobenzene, metabolism was affected by aging only in liver and lung cytosol from males. Finally, with 1-chloro-2,4-dinitrobenzene, metabolic rates were altered during aging only with liver cytosol from females. However, the apparent Km was higher with liver cytosol from old males; those values from lung cytosol of males and liver or lung cytosol from females were unchanged. These data indicate that changes in the cytosolic glutathione S-transferase isozymes occurred during aging. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Animals Cytotoxins Lung Occupational Health Respiratory System Safety Sex Characteristics
• Keywords:
  Age Factors Animal Studies Cytotoxic Effects Lithium Hydroxide Lung Tissue Sex Factors
• ISSN:
  0006-2952
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Florida ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  33
• Issue:
  8
• NIOSHTIC Number:
  nn:20060642
• Citation:
  Biochem Pharmacol 1984 Apr; 33(8):1309-1313
• Contact Point Address:
  Prof. Kenneth C. Leibman, Department of Pharmacology and Therapeutics, University of Florida, J.H. Miller Health Center Box J-267, Gainsville, FL 32610, U.S.A.
• Federal Fiscal Year:
  1984
• Performing Organization:
  University of Florida Gainesville, Gainesville, Florida
• Peer Reviewed:
  True
• Start Date:
  19710101
• Source Full Name:
  Biochemical Pharmacology
• End Date:
  19841130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9d3df3d3b07039e8e94c45b4e8ad2018e0bfa6ea9bb486615a38685129e04a045195e7d8f7f00352393c595d7a7c77ec68d7b90cc4afde4df6e866b98b59b541
• Download URL:
  https://stacks.cdc.gov/view/cdc/224492/cdc_224492_DS1.pdf
• File Type:
  [PDF - 566.04 KB ]