Microfabricated Porous Layer Open Tubular (PLOT) Column

Details

• Personal Author:
  Fan X ; Li MW-H ; Li Z ; She J ; Zhu H
• Description:
  Development of micro gas chromatography (uGC) is aimed at rapid and in situ analysis of volatile organic compounds (VOCs) for environmental protection, industrial monitoring, and toxicology. However, due to the lack of appropriate microcolumns and associated stationary phases, current uGC is unable to separate highly volatile chemicals such as methane, methanol, and formaldehyde, which are of great interest for their high toxicity and carcinogenicity. This inability has significantly limited uGC field applicability. To address this deficiency, this paper reports the development and characterization of a microfabricated porous layer open tubular (uPLOT) column with a divinylbenzene-based stationary phase. The separation capabilities of the uPLOT column are demonstrated by three distinct analyses of light alkanes, formaldehyde solution, and organic solvents, exhibiting its general utility for a wide range of highly volatile compounds. Further characterization shows the robust performance of the uPLOT column in the presence of high moisture and at high temperatures (up to 300 degrees C). The small footprint and the ability to separate highly volatile chemicals make the uPLOT column highly suitable for integration into uGC systems, thus significantly broadening uGC's applicability to rapid, field analysis of VOCs. [Description provided by NIOSH]
• Subjects:
  Chemistry Laboratories Occupational Health Safety Volatile Organic Compounds
• Keywords:
  Chemical Analysis Equipment Design Gas Chromatography Laboratory Equipment Porous Materials VOCs Volatile Organic Compounds
• ISSN:
  1473-0197
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  23
• NIOSHTIC Number:
  nn:20060619
• Citation:
  Lab Chip 2019 Dec; 19(23):3979-3987
• Contact Point Address:
  Xudong Fan, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
• Email:
  xsfan@umich.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Michigan at Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20180901
• Source Full Name:
  Lab on a Chip
• End Date:
  20220831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2ff55ea3de8a91fe140b398704ae1c5ea84b56264f6bb8d76a870396a423c8689afc32b425c39f99149fca742873079cc55913af3be3bae54094372f75bfc2bf
• Download URL:
  https://stacks.cdc.gov/view/cdc/224475/cdc_224475_DS1.pdf
• File Type:
  [PDF - 2.58 MB ]