Effect of Topical Application of 13-Cis Retinoic Acid on Skin of Hairless Rats and Hairless Mice

Details

• Personal Author:
  Puhvel SM ; Sakamoto M
• Description:
  The potential effectiveness of topical 13-cis retinoic acid (13-cis RA) as a sebosuppressive agent was evaluated in hairless ("fuzzy") rats and hairless mice. At nontoxic dosages (i.e., concentrations which induced no weight loss), topical 13-cis RA had no detectable sebosuppressive effects in either of these species. In hairless rats, the topical application of 0.2% 13-cis RA induced more severe symptoms of toxicity than was induced by the administration of equivalent amounts of the drug by either oral or subcutaneous routes. Due to variability in species sensitivity to 13-cis RA, the potential effectiveness of the topical use of this retinoid can probably only be evaluated in human volunteers. [Description provided by NIOSH]
• Subjects:
  Animals Occupational Health Safety Skin Toxicology
• Keywords:
  Animal Studies Author Keywords: 13-Cis Retinoic Acid Dermatology Epidermis Hairless Mice Hairless Rats Sebum Production Skin Exposure Toxic Effects
• ISSN:
  0340-3696
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  395-399
• Volume:
  277
• Issue:
  5
• NIOSHTIC Number:
  nn:20060569
• Citation:
  Arch Dermatol Res 1985 Sep; 277(5):395-399
• Contact Point Address:
  Dr. S. M. Puhvel, Division of Dermatology, Department of Medicine, UCLA Center for Health Sciences, UCLA School of Medicine, Los Angeles, CA 90024, USA
• Federal Fiscal Year:
  1985
• Performing Organization:
  University of California Los Angeles, Los Angeles, California
• Peer Reviewed:
  True
• Start Date:
  19800929
• Source Full Name:
  Archives of Dermatological Research
• End Date:
  19870630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1ffc6c03bac74515169bed5959b4903270476de5bb7ed27a94f4d433e32bbed4cecc268e9f98182b93a07f47a8a3c3a6d8af1b04f51bd283d21daecab8d3ee0c
• Download URL:
  https://stacks.cdc.gov/view/cdc/224434/cdc_224434_DS1.pdf
• File Type:
  [PDF - 182.91 KB ]