Phthalates and Human Health

Details

• Personal Author:
  Calafat A ; Hauser R
• Description:
  The diesters of 1,2-benzenedicarboxylic acid (phthalic acid), commonly known as phthalates, are a group of man-made chemicals with a wide spectrum of industrial applications (fig 1, table 1). High molecular weight phthalates (for example, di(2-ethylhexyl) phthalate [DEHP], di-isononyl phthalate [DiNP], di-n-octyl phthalate [DnOP]), are primarily used as plasticizers in the manufacture of flexible vinyl which, in turn, is used in consumer products, flooring and wall coverings, food contact applications, and medical devices. Manufacturers use low molecular weight phthalates (for example, diethyl phthalate [DEP] and dibutyl phthalate [DBP]) in personal-care products (for example, perfumes, lotions, cosmetics), as solvents and plasticizers for cellulose acetate, and in making lacquers, varnishes, and coatings, including those used to provide timed releases in some pharmaceuticals. In this paper, we review the uses and metabolism of phthalates, and the studies on health effects of phthalates in human populations published between 1973 and June 2005. The references included in this review were searched using the Web of Science database which provides interactive citation and literature searching of the Institute for Scientific Information's Science Citation Index Expanded. The database contains data from more than 5000 scientific journals and covers the period from 1980 to present. We also searched the bibliography cited in the selected references for additional relevant citations. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Occupational Health Phthalic Acids Plastics Safety
• Keywords:
  Chemicals Di(2-ethylhexyl) Phthalate Dibutyl Phthalate Diethyl Phthalate Health Effects Metabolism Phthalates Plasticizers Vinyl Plastics
• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  62
• Issue:
  11
• NIOSHTIC Number:
  nn:20060386
• Citation:
  Occup Environ Med 2005 Nov; 62(11):806-818
• Contact Point Address:
  Prof. Associate R Hauser, Occupational Health Program, Harvard School of Public Health, Building 1, Room 1405, 665 Huntington Avenue, Boston, MA 02115
• Email:
  rhauser@hohp.harvard.edu
• CAS Registry Number:
  Butyl benzyl phthalate (CAS RN 85-68-7) ; Dibutyl phthalate (CAS RN 84-74-2) ; Diethyl phthalate (CAS RN 84-66-2)
• Federal Fiscal Year:
  2006
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5a2ed241595d1a7f2f1dde7687819912f418837779da250a87df30d48ad3b9dfbdd30f9f61f458acb0b52cfe3497c9c4b01db98f0914443ac2411d50defd9696
• Download URL:
  https://stacks.cdc.gov/view/cdc/224316/cdc_224316_DS1.pdf
• File Type:
  [PDF - 178.11 KB ]