Early Cellular Events in Pulmonary Fibrosis

Details

• Personal Author:
  Last JA ; Reiser KM
• Description:
  Although the precise definition of pulmonary fibrosis depends to some extent on one's discipline, for the purposes of this review it will be somewhat loosely defined as "abnormal deposition of collagen in the lung." The abnormality may thus be construed to be aberrations in the amount of collagen, the site of collagen deposition, and/or the nature of the collagen itself. This review will focus on early events, at both the cellular and molecular level, that culminate in such abnormalities. The lung is a particularly complex organ to study in this respect as there are many cell types present whose function is often poorly understood, even in normal lungs. Clearly it would be impossible to review the vast literature on cellular defense mechanisms in the lung in a single paper. This review will thus focus selectively on what is currently known about lung cell function and interaction during the early phases of specific types of pulmonary fibrosis. Studies discussed will illustrate the range of experimental approaches available for investigating early cellular events, both in animal models and in human diseases. Although the various cell types present in the lung are probably constantly interacting during fibrogenesis, our knowledge is too fragmentary at this point to present a coherent picture of all their interactions chronologically. Thus, cell types will be considered individually in terms of their behavior and response to various types of fibrogenic stimuli. Of particular interest is the question of how stereotyped is the lung's response to fibrogenic stimuli. Can we detect, for example, important differences in the sequence of cellular events following administration of particulate, gaseous, and systemic fibrogens: If so, is there a "final common pathway" to fibrosis at a certain point? Of interest also is the question of how fibrosis induced by known etiologic agents compares with the human fibrotic diseases of unknown etiology. [Description provided by NIOSH]
• Subjects:
  Fibrosis Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Cellular Effects Collagen Fibrils Etiology Lung Disorders Lung Tissue Pulmonary Disorders Respiratory Diseases
• ISSN:
  0190-2148
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  331-355
• Volume:
  10
• Issue:
  4
• NIOSHTIC Number:
  nn:20060374
• Citation:
  Exp Lung Res 1986 Jul; 10(4):331-355
• Contact Point Address:
  Jerold A. Last, Ph.D., California Primate Research Center, University of California, Davis, CA 95616
• Federal Fiscal Year:
  1986
• Performing Organization:
  University of California Davis, Davis, California
• Peer Reviewed:
  True
• Start Date:
  19840928
• Source Full Name:
  Experimental Lung Research
• End Date:
  19870831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:82e87e20461afc3c9ac5412ce701cdcbced28a4fa1bb50953f979d3c4495718310cd3cdd9fb6f5b353191c86a80f78723ace9900a996643be01f8736af6ce5b8
• Download URL:
  https://stacks.cdc.gov/view/cdc/224308/cdc_224308_DS1.pdf
• File Type:
  [PDF - 491.25 KB ]