Carbon Monoxide Inhibits Monooxygenation by the Conceptus and Embryotoxic Effects of Proteratogens In Vitro

Details

• Personal Author:
  Faustman-Watts EM ; Giachelli CM ; Juchau MR ; Faustman-Watts EM ; Giachelli CM ; Juchau MR
• Description:
  Evidence that Day 10 to 11 rat conceptuses can contain sufficient quantities of xenobiotic-oxidizing P-450(s) to catalyze the conversion of proteratogens to reactive teratogenic intermediates is presented. Quantities of reactive intermediates generated by conceptuses from 2-acetylaminofluorene (AAF) were sufficient to result in the appearance of gross morphologic abnormalities with a high incidence of neural tube anomalies. Carbon monoxide effectively inhibited the conversion of AAF to hydroxylated metabolites by rat conceptuses, and also inhibited the capacity of AAF to elicit neural tube anomalies in cultured embryos. Inhibition by CO of either parameter was observed only with conceptuses exposed in utero to the potent P-450 inducer, 3-methylcholanthrene. [Description provided by NIOSH]
• Subjects:
  Animals Biochemistry Carbon Monoxide Occupational Health Safety Teratogenesis
• Keywords:
  Animal Studies Carbon Monoxide In Utero Exposure In Utero Study Pharmacology Teratogens
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  83
• Issue:
  3
• NIOSHTIC Number:
  nn:20060317
• Citation:
  Toxicol Appl Pharmacol 1986 May; 83(3):590-595
• Contact Point Address:
  Mont R. Juchau, Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington 98195
• CAS Registry Number:
  Carbon monoxide (CAS RN 630-08-0) ; Carbon monoxide (CAS RN 630-08-0)
• Federal Fiscal Year:
  1986
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Applied Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5f5cd1ffcd470255b72ec8ea56d7149e8ab51998d56c88e16a16f1ce4f3420dc8cb437d4dd22309753a53d3eb7ccef111fabb73294953220b9674396ba2c2651
• Download URL:
  https://stacks.cdc.gov/view/cdc/224259/cdc_224259_DS1.pdf
• File Type:
  [PDF - 460.06 KB ]