Hair and Metal Toxicity

Details

• Personal Author:
  Christiani, David C. ; Kales SN
• Description:
  Hair is most relevant to metals toxicology as a biological medium or biopsy material for analysis. Hair can be non-invasively obtained, easily stored and transported, and later analysed for the presence of certain matals. Hair analysis is most informative when the metal of interest is a xenobiotic and the exposure route is ingestion. In these cases, it is most likely that hair analysis reflects an internal dose of the metal and not external contamination of the hair. Determination of hair mercury to estimate dietary methylmercury exposure is the best example. A large body of epidemiological evidence correlates hair mercury concentrations to blood mercury levels and both of these to fish consumption in a dose-response fashion. In addition, hair is one of several biomarkers used in epidemiological studies of arsenicosis and arsenic-contaminated drinking water. Further, hair analysis can be used clinically and forensically to document thallium poisoning, an intoxication that also results in pathological changes in the hair. [Description provided by NIOSH]
• Subjects:
  Arsenic Biomarkers Blood Environmental Exposure Epidemiology Hematologic Tests Inorganic Chemicals Mercury Metals Occupational Health Pathology Poisoning Safety Toxicology

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• Keywords:
  Arsenic Compounds Biological Effects Biopsy Blood Samples Dose Response Exposure Levels Hair Analysis Poisons Thallium Thallium Compounds Xenobiotics

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• ISBN:
  9780854045877
• Publisher:
  Royal Society of Chemistry
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  125-153
• NIOSHTIC Number:
  nn:20060266
• Citation:
  Hair in toxicology: an important bio-monitor. Tobin DJ ed. Cambridge, UK: Royal Society of Chemistry, 2005 Jan; :125-153
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2) ; Mercury (CAS RN 7439-97-6) ; Methylmercury(1+) (CAS RN 22967-92-6)
• Editor(s):
  Tobin DJ
• Federal Fiscal Year:
  2005
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  False
• Start Date:
  20030701
• Source Full Name:
  Hair and metal toxicity
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4c71628b0404b593bec48ab9f1c96225d9bf06b311a5178bdaedd2d7721783e7b372928c96a8411ece5ce748bb4d1cdabcc849cbb1d8ed1abce97f823c8d9609
• Download URL:
  https://stacks.cdc.gov/view/cdc/224222/cdc_224222_DS1.pdf
• File Type:
  [PDF - 228.17 KB ]