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Metabolism and Excretion of Gallium Arsenide and Arsenic Oxides by Hamsters Following Intratracheal Instillation



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  • Personal Author:
  • Description:
    The increasing use of gallium arsenide (GaAs) in the electronics industry has produced the need for pharmacokinetic and toxicologic data on GaAs. The disposition in male Syrian golden hamsters (n=4) following intratracheal instillation of GaAs (mean volume diameter 5.8 microm), arsenic(III) oxide (arsenite), and arsenic(V) oxide (arsenate) at a dose of 5 mg/kg body weight was examined. Blood, kidney, liver, and lung samples were collected at 1, 2, and 4 days after administration. Excreta were collected daily. Urinary metabolite profiles were determined after separation on a mixed anion-cation-exchange column. Total As content was analyzed by direct hydride flame atomic absorption spectrophotometry after digestion. Arsenic blood levels after GaAs, arsenite, and arsenate administration were 0.185 +/- 0.041, 0.596 +/- 0.117, and 0.310 +/- 0.045 ppm, respectively, after Day 1. Arsenic blood levels after GaAs administration increased to 0.279 +/- 0.021 ppm on Day 2 indicating continued absorption while levels decreased for the arsenite and arsenate groups. At Day 1 the liver contained 0.565 +/- 0.036, 2.62 +/- 0.26, and 0.579 +/- 0.144% of the arsenic dose of GaAs, arsenite, and arsenate, respectively. The arsenite and arsenate were rapidly excreted in the urine with almost half the dose appearing after 4 days; in contrast, only about 5% of the GaAs was found at the corresponding time. Total recoveries, as arsenic equivalents, for the three compounds were between 75 and 80%. Ratios of the two major urinary metabolites (dimethylarsinic acid/total inorganic As species) were 1.41, 1.71, and 0.983 for GaAs, arsenite, and arsenate, respectively. GaAs is metabolized to the same compounds as arsenite and arsenate, and shows a metabolic profile most similar to that observed for sodium arsenite. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    0272-0590
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    9
  • Issue:
    4
  • NIOSHTIC Number:
    nn:20060212
  • Citation:
    Fundam Appl Toxicol 1987 Nov; 9(4):730-737
  • CAS Registry Number:
  • Federal Fiscal Year:
    1988
  • Performing Organization:
    University of Arizona, Tuscon
  • Peer Reviewed:
    True
  • Start Date:
    19841101
  • Source Full Name:
    Fundamental and Applied Toxicology
  • End Date:
    19881031
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:1e4b4172a1a0e61e543b9412bc5f231bdc4086026950985c55f682d641d77a4209613567aadbd71af92bf9d8ef4f726d0dbc2554bccd1889b6979bf20e8ffc6f
  • Download URL:
  • File Type:
    Filetype[PDF - 731.61 KB ]
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