Effect of Hexacarbons on Selected Lipids in Developing Rat Brain and Peripheral Nerves

Details

• Personal Author:
  Bhatt A ; Khan S ; Pandya KP ; Sabri MI
• Description:
  The effects of neurotoxic solvents, i.e. 2,5-hexanedione (2,5-HD), 2,5-hexanediol (2,5-HDiol) and the non-neurotoxic solvent, 2,4-hexanedione (2,4-HD) (500 mg/kg body wt./day, i.p.), have been studied on the lipid composition of brain and sciatic nerves in weanling rats. Five-day-old rats were administered a solvent daily for 21 days. Clinical signs of peripheral neuropathy appeared in 2,5-HD and 2,5-HDiol treated groups. Absolute weights of brain, spleen, thymus significantly decreased with 2,5-HD. Cholesterol content in whole brain homogenates and myelin was significantly reduced with 2,5-HD and 2,5-HDiol treatment. There was also a significant reduction in ubiquinone content of brain with 2,5-HD and 2,5-HDiol treatment. On exposure to neurotoxic chemicals to weanling rats, significant alteration in lipid profile was observed in the brain, which may be one of the key factors in the development of neuropathy. [Description provided by NIOSH]
• Subjects:
  Animals Lipids Nervous System Occupational Health Safety Solvents
• Keywords:
  2,5-hexanediol 2,5-hexanedione Animal Studies Author Keywords: Hexacarbon Neurotoxicity Brain Function Energy Metabolism Neurological System Neuropathy Neurotoxic Effects Neurotoxins Polyneuropathy Sterol Ubiquinone

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• ISSN:
  0260-437X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  53-57
• Volume:
  8
• Issue:
  1
• NIOSHTIC Number:
  nn:20060129
• Citation:
  J Appl Toxicol 1988 Feb; 8(1):53-57
• Contact Point Address:
  K. P. Pandya, Industrial Toxicology Research Centre, P.O. Box 80. M.G. Marg. Lucknow-226 001, India
• CAS Registry Number:
  2,5-Hexanediol (CAS RN 2935-44-6) ; 2,5-Hexanedione (CAS RN 110-13-4)
• Federal Fiscal Year:
  1988
• Performing Organization:
  Yeshiva University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19800501
• Source Full Name:
  Journal of Applied Toxicology
• End Date:
  19890430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:42427eafb11376dfb4b9c5c8082b8df4b3e942a7109ef3a97d6f7f63ba656fa676f58f23b8bf3ef95f85760bc664b9dd734b130e1842cb583477ab336d672958
• Download URL:
  https://stacks.cdc.gov/view/cdc/224138/cdc_224138_DS1.pdf
• File Type:
  [PDF - 367.51 KB ]