Immunotoxicity of Sulfuric Acid Aerosol: Effects on Pulmonary Macrophage Effector and Functional Activities Critical for Maintaining Host Resistance Against Infectious Diseases

Details

• Personal Author:
  Cohen MD ; Schlesinger RB ; Sisco MP ; Yang Z ; Zelikoff JT
• Description:
  Despite the widespread occurrence of acidic sulfur oxides in the ambient environment and their potential risks to human health, effects associated with pulmonary immune defenses have been poorly studied. The current in vivo study was designed to provide some insight into this relatively unexplored area by investigating the impact of inhaled sulfuric acid on immune defense mechanisms critical for maintaining pulmonary resistance against infectious diseases. Results of this study demonstrate that repeated inhalation of sulfuric acid reduces the uptake and intracellular killing of pathogenic bacteria by exposed pulmonary macrophages, and depresses the activity/production of important biological modifiers critical for maintaining pulmonary immunocompetence. These findings have important implications for human health, and may contribute to a better understanding of the possible mechanism(s) underlying the epidemiological evidence which suggests an association between total sulfates in the ambient air and increased incidence of acute bronchitis and lower respiratory illness in school-age children. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollution Blood Communicable Diseases Immune System Lung Macrophages Occupational Health Respiratory System Safety Toxicology

  More +
• Keywords:
  Air Pollution Author Keywords: Macrophage Health Effects Immune Reaction Immunosuppression Infectious Diseases Pollutants Pulmonary Defense Pulmonary Effects Sulfuric Acid Toxic Effects

  More +
• ISSN:
  0300-483X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  269-286
• Volume:
  92
• Issue:
  1
• NIOSHTIC Number:
  nn:20060112
• Citation:
  Toxicology 1994 Sep; 92(1-3):269-286
• Contact Point Address:
  Judith T. Zelikoff, Institute of Environmental Medicine, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA
• CAS Registry Number:
  Sulfuric acid (CAS RN 7664-93-9)
• Federal Fiscal Year:
  1994
• Performing Organization:
  Mount Sinai School of Medicine, New York
• Peer Reviewed:
  True
• Start Date:
  19920701
• Source Full Name:
  Toxicology
• End Date:
  19970630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6df9f90d5f6d2f6d95c1e6bcec68ba133e2f167d3120ba190d43f9857b28ba1a3f22b673368769b854d0831a513b214cece685906142d92cdb79eb2fd5e5fb2c
• Download URL:
  https://stacks.cdc.gov/view/cdc/224126/cdc_224126_DS1.pdf
• File Type:
  [PDF - 1.03 MB ]