Deposition of Inhaled Charged Ultrafine Particles in a Simple Tracheal Model

Details

• Personal Author:
  Asgharian B ; Ayres L ; Cohen BS ; Xiong JQ
• Description:
  The deposition of ultrafine (d ≤200 nm) particles on airway surfaces is an important determinant of the radiation dose that results from inhalation of radon progeny. Diffusion is the dominant deposition mechanism for radon progeny since most of the alpha particle activity is on ultrafine particles. Freshly formed 218Po is rapidly neutralized but, there remains some charged fraction of each short-lived decay product. Theoretical predictions suggest that a measurable increase in airway deposition may result from particle charge. We have measured and compared the deposition (n) of monodisperse singly charged, and charge neutralized, particles with diameters from 15 to 95 nm in simple tracheal models. Differences in deposition were detectable for particles < 30 nm in diameter in 10, 23 and 30 cm long tubes, and for particles up to 95 nm for the longest (30 cm) tube tested. Variations in the magnitude of electrostatic deposition with particle and flow parameters is consistent with theoretical predictions. [Description provided by NIOSH]
• Subjects:
  Occupational Health Respiratory System Safety
• Keywords:
  Inhalation Inhalation Studies Particle Aerodynamics Radiation Exposure Radon Daughters Ultrafine Particles
• ISSN:
  0021-8502
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  26
• Issue:
  7
• NIOSHTIC Number:
  nn:20060097
• Citation:
  J Aerosol Sci 1995 Oct; 26(7):1149-1160
• Contact Point Address:
  Beverly S. Cohen, Lanza Laboratory, Nelson Institute of Environmental Medicine, New York University Medical Center, Long Meadow Road, Tuxedo, NY 10987, U.S.A.
• CAS Registry Number:
  Radon (CAS RN 10043-92-2)
• Federal Fiscal Year:
  1996
• Performing Organization:
  Mount Sinai School of Medicine, New York
• Peer Reviewed:
  True
• Start Date:
  19920701
• Source Full Name:
  Journal of Aerosol Science
• End Date:
  19970630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:369ac080644c3c94309096a423fe15196f8d77aa47c1b71ada80b13fabb7c21c479249a28409a6334cfce1989bfd4fe4744f8571c5b22257753a744cb3407346
• Download URL:
  https://stacks.cdc.gov/view/cdc/224118/cdc_224118_DS1.pdf
• File Type:
  [PDF - 693.32 KB ]