Enhanced Risk of Lung and Prostate Adenocarcinoma in African-American Smokers Carrying a Novel CYP1A1 Gene Polymorphism

Details

• Personal Author:
  Crofts F ; Demopoulos R ; Garte SJ ; Li YL ; Taioli E ; Trachman J
• Description:
  The CYP1A1 gene codes for aromatic hydrocarbon hydroxlase (AHH), a critical enzyme in the metabolism of carcinogenic polycyclic aromatic hydrocarbons. Polymorphisms in this gene have been implicated in aberrant gene function, and in increased risk of cancer from exposure to hydrocarbons such as those found in tobacco smoke. We have discovered a novel restriction polymorphism ("AA RFLP") in this gene that is found only in people of African descent. African Americans suffer a disproportionate high incidence of lung and prostate cancer. This is not due to increased smoking, but may be related to either environmental or genetic factors. We have examined the possibility that the African American specific CYP1A1 RFLP may be associated with higher risk for tobacco related carcinogenesis. The incidence of the AA polymorphism in the healthy African-American population was 14.5%. In African-Americans with adenocarcinoma of the lung the incidence of the polymorphism was doubled. We observed no difference between cases and controls in the incidence of the exon 7 polymorphism of the CYP1A1 gene. A preliminary study was conducted on tissue cks from African-American prostate cancer patients. Overall, the AA RFLP was not significantly associated with prostate cancer; however, subjects who both smoke and carry the AA RFLP have significantly higher risk of prostate cancer than subjects who either smoke alone, or carry the AA RFLP alone. This study represents a model for investigation of gene-environment interactions related to PAH induced carcinogenesis. [Description provided by NIOSH]
• Subjects:
  Genetics Hydrocarbons Lung Lung Diseases Neoplasms Occupational Health Polycyclic Aromatic Hydrocarbons Race Factors Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smokers

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• Keywords:
  Author Keywords: Genetic Susceptibility Deoxyribonucleic Acids DNA Environment Gene-environment Interaction Genes Genetic Factors Lung Cancer Polycyclic Aromatic Hydrocarbons Prostate Cancer Racial Factors Risk Factors Smoking Tobacco Metabolism

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• ISSN:
  1040-6638
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  19-26
• Volume:
  11
• Issue:
  1
• NIOSHTIC Number:
  nn:20060060
• Citation:
  Polycycl Aromat Compd 1996 Dec; 11(1-4):19-26
• Contact Point Address:
  Emanuela Taioli, Department of Environmental Medicine, New York University, Medical Center, 341 East 25th Street, United States
• Federal Fiscal Year:
  1997
• Performing Organization:
  Mount Sinai School of Medicine, New York
• Peer Reviewed:
  True
• Start Date:
  19920701
• Source Full Name:
  Polycyclic Aromatic Compounds
• End Date:
  19970630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c72ba4cbc40bd424f8b530bdff4e30b5461c51fa512e4ec8e6369fcf6a5e3364e552e8ca290fe1a52b001f5df4da9de24677f15161740748733ae429431c795c
• Download URL:
  https://stacks.cdc.gov/view/cdc/224093/cdc_224093_DS1.pdf
• File Type:
  [PDF - 502.78 KB ]