Increased Pulmonary Response to Inhaled Endotoxin in Lactating Rats

Details

• Personal Author:
  Gordon T ; Gunnison AF ; Weideman PA
• Description:
  An important aspect of risk assessment is identification of subpopulations particularly susceptible to the effects of inhaled pollutants. The present study examined whether female rats were more sensitive during lactation to the acute pulmonary injury produced by inhaled endotoxin. Lactating and age-matched virgin female rats were exposed to aerosols of saline or endotoxin for 3 h and lavaged at 24 h after exposure. No significant differences in lactate dehydrogenase, beta-glucuronidase, total protein, and total cell and PMN counts were observed between virgin and lactating rats after exposure to saline. Each marker of pulmonary injury except beta-glucuronidase was 1.5- to 3-fold greater in lactating than in virgin female rats exposed to 29.6 micro g/m3 endotoxin. PMNs (6-fold), total cell counts, and protein were also significantly increased (p < 0.05) in lactating rats exposed to 1.3 micro g/m3 endotoxin, a concentration reported to occur in a number of agricultural settings. These results demonstrate that the physiologic state of lactation is associated with an increased sensitivity to the acute pulmonary injury produced by inhaled endotoxin and are consistent with previous work demonstrating a similar increased sensitivity to ozone exposure. The possibility of a similar pattern of enhanced response in analogous groups of humans merits examination. [Description provided by NIOSH]
• Subjects:
  Agriculture Animals Endotoxins Lung Occupational Health Respiratory System Safety
• Keywords:
  Animal Studies Inhalation Studies Pollutants Pulmonary Effects Risk Assessment
• ISSN:
  0003-0805
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  147
• Issue:
  5
• NIOSHTIC Number:
  nn:20060034
• Citation:
  Am Rev Respir Dis 1993 May; 147(5):1100-1104
• Contact Point Address:
  Terry Gordon, Ph.D., Department of Environmental Medicine, NYU Medical Center, A.J. Lanza Laboratory, Long Meadow Road, Tuxedo, NY 10987
• Federal Fiscal Year:
  1993
• Performing Organization:
  Mount Sinai School of Medicine, New York
• Peer Reviewed:
  True
• Start Date:
  19920701
• Source Full Name:
  American Review of Respiratory Disease
• End Date:
  19970630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:22a8ff429766821e555b81825a119fee99821b30d255dfc5fc6c13fd78fd865f006a24509724b967300a9475bb3d2f233c1b8155dc122a508ff683f428c807ef
• Download URL:
  https://stacks.cdc.gov/view/cdc/224070/cdc_224070_DS1.pdf
• File Type:
  [PDF - 647.70 KB ]