Spontaneous Abortions and Congenital Malformations Among the Wives of Men Occupationally Exposed to Organic Solvents

Details

• Personal Author:
  Anttila A ; Hemminki K ; Lindbohm M-L ; Sallmén M ; Taskinen H
• Description:
  A case-referent study nested in a cohort monitored biologically for exposure to six organic solvents (styrene, toluene, xylene, tetrachloroethylene, trichloroethylene, and 1,1,1-trichloroethane) was conducted to investigate the effects of paternal exposure on pregnancy outcome. The pregnancies were identified from medical registers. The exposures of the men during the spermatogenesis preceding the pregnancies and of the women during the first trimester of the pregnancies were obtained with questionnaires, and the available biological monitoring measurements were used in the exposure assessment. Factors which significantly increased the odds ratio of spontaneous abortion were paternal exposure to organic solvents in general, high/frequent exposure to toluene or miscellaneous organic solvents (including thinners), and maternal heavy lifting. No significant association between paternal or maternal exposure and congenital malformations was found, but because of the few cases no firm conclusions can be drawn. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Men Occupational Exposure Occupational Health Pregnancy Safety Solvents Spermatogenesis Trichloroethanes Trichloroethylene Urogenital System Women

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• Keywords:
  1,1,1-trichloroethane Author Keywords: Biological Monitoring Biological Monitoring Cohort Studies Exposure Assessment Occupational Exposure Organic Solvents Paternal Exposure Reproductive Hazards Styrene Tetrachloroethylene Toluene Trichloroethylene Xylene

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• ISSN:
  0355-3140
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  345-352
• Volume:
  15
• Issue:
  5
• NIOSHTIC Number:
  nn:20060015
• Citation:
  Scand J Work Environ Health 1989 Oct; 15(5):345-352
• Contact Point Address:
  Dr H Taskinen, Institute of Occupational Health, Topeliuksenkatu 41 a A, SF-00250 Helsinki, Finland
• CAS Registry Number:
  1,1,1-Trichloroethane (CAS RN 71-55-6) ; Styrene (CAS RN 100-42-5) ; Tetrachloroethylene (CAS RN 127-18-4) ; Toluene (CAS RN 108-88-3) ; Trichloroethylene (CAS RN 79-01-6) ; Xylene (CAS RN 1330-20-7)
• Federal Fiscal Year:
  1990
• Peer Reviewed:
  True
• Source Full Name:
  Scandinavian Journal of Work, Environment & Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:632e9e5bc5393412bf988cac3072a34264459839470a5540219f453340a5785646f5f87ce8a1d8547a379db6b8766538919d4ce32ef5471ae4b11aca7d33d6e2
• Download URL:
  https://stacks.cdc.gov/view/cdc/224053/cdc_224053_DS1.pdf
• File Type:
  [PDF - 5.01 MB ]