Absence of Tubular Proteinuria Following Environmental Exposure to Chromium

Details

• Personal Author:
  De Broe ME ; D'Haese PC ; Elseviers M ; Haque S ; Udasin I ; Wedeen RP
• Description:
  Certain chromium compounds are known to be nephrotoxic, but renal damage from long-term environmental or occupational exposure to chromium has not been documented. To detect possible preclinical renal damage, we tested the urine of 55 lifelong residents of an area contaminated with chromium landfill. The levels of four proteins were determined in urine samples: (1) human intestinal alkaline phosphatase, (2) tissue nonspecific alkaline phosphatase, (3) N-acetyl-ß-D-glucosaminidase, and (4) microalbumin. No elevated levels of proteins were found, and there were no significant correlations between urine protein and urine chromium concentrations. We concluded that long-term environmental exposure to chromium dust did not lead to tubular proteinuria. [Description provided by NIOSH]
• Subjects:
  Chromium Environmental Exposure Kidney Diseases Occupational Exposure Occupational Health Safety Urogenital Diseases Urogenital System
• Keywords:
  Chromium Compounds Environmental Exposure Exposure Assessment Nephrotoxins Occupational Exposure Proteins Renal Toxicity
• ISSN:
  0003-9896
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New Jersey ; New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  321-323
• Volume:
  51
• Issue:
  4
• NIOSHTIC Number:
  nn:20059980
• Citation:
  Arch Environ Health 1996 Jul-Aug; 51(4):321-323
• Contact Point Address:
  Richard P. Wedeen, Department of Veterans Affairs, Medical Center, 385 Tremont Avenue, East Orange, NJ 07018-1095
• CAS Registry Number:
  Chromium (CAS RN 7440-47-3)
• Federal Fiscal Year:
  1996
• Performing Organization:
  Mount Sinai School of Medicine, New York
• Peer Reviewed:
  True
• Start Date:
  19920701
• Source Full Name:
  Archives of Environmental Health
• End Date:
  19970630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:18d19cbd7e82e8139b34affa80c6804b36256bf419f03b98abe24a257820d6a5f3c53af95c52d9d1c37b447a5434691eb562dcfe3cf863ebf16b901c3cb5f25b
• Download URL:
  https://stacks.cdc.gov/view/cdc/224028/cdc_224028_DS1.pdf
• File Type:
  [PDF - 426.17 KB ]