Unraveling the Chronic Toxicity of Lead: An Essential Priority for Environmental Health

Details

• Personal Author:
  Godbold JH ; Landrigan, Philip J. ; Levin SM ; Moline JM ; Todd AC ; Wetmur JG ; Godbold JH ; Landrigan, Philip J. ; Levin SM ; Moline JM ; Todd AC ; Wetmur JG
• Description:
  Although population exposure to lead has declined, chronic lead toxicity remains a major public health problem in the United States affecting millions of children and adults. Important gaps exist in knowledge of the pathophysiology of chronic lead intoxication. These gaps have impeded development of control strategies. To close current gaps in knowledge of chronic lead toxicity, we propose an integrated, multidisciplinary, marker-based research program. This program combines a) direct measurement of individual lead burden by 109Cd X-ray fluorescence analysis of lead in bone, b) determination of ALA-D phenotype, an index of individual susceptibility to lead, and c) assessments of subclinical injury produced by lead in the kidneys, nervous system and, reproductive organs. Data from this research will provide answers to questions of great public health importance: a) Are current environmental and occupational standards adequate to prevent chronic lead intoxication? b) is lead mobilized from the skeleton during pregnancy or lactation to cause fetal toxicity? c) Is lead mobilized from bone during menopause to cause neurotoxicity? d) What is the significance of genetic variation in determining susceptibility to lead? e) What is the contribution of lead to hypertension, renal disease, chronic neurodegenerative disease or declining sperm counts? f) Is chelation therapy effective in reducing body lead burden in persons with chronic overexposure to lead? [Description provided by NIOSH]
• Subjects:
  Biomarkers Environmental Exposure Lead Nervous System Occupational Exposure Occupational Health Safety
• Keywords:
  ALAD Author Keywords: Lead Biological Monitoring Chronic Exposure Environmental Exposure Nephrotoxicity Neurotoxic Effects Neurotoxicity Reproductive Toxicity Skeletal Lead Skeletal System Toxic Effects

  More +
• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  141-146
• Volume:
  104
• NIOSHTIC Number:
  nn:20059904
• Citation:
  Environ Health Perspect 1996 Mar; 104(Suppl 1):141-146
• Contact Point Address:
  Dr. Philip J. Landrigan, Environmental Health Sciences Center, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029
• Email:
  pJlandrigan@smtplink.mssm.edu
• CAS Registry Number:
  Lead (CAS RN 7439-92-1) ; Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  1996
• Performing Organization:
  Mount Sinai School of Medicine, New York
• Peer Reviewed:
  True
• Start Date:
  19920701
• Source Full Name:
  Environmental Health Perspectives
• Supplement:
  1
• End Date:
  19970630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:632e2ed818cd6603179688d7029ea106102ec2ed7d1ee9463ee6b458985a8175e6de1bd4a35da1bb2a3c3cd3eee4bbb63606e05bc7da3e64d6806953d5f8f86e
• Download URL:
  https://stacks.cdc.gov/view/cdc/223958/cdc_223958_DS1.pdf
• File Type:
  [PDF - 1.29 MB ]