Identifying Risk Factors for Cholinesterase Depression Among Pesticide Handlers in Washington State

Details

• Personal Author:
  Checkoway, Harvey ; De Roos A ; Fenske R ; Furlong C ; Hofmann J ; Keifer, Max
• Description:
  In 2004, the Washington State Department of Labor and Industries (L&I), under mandate from the Washington State Supreme Court, initiated a new cholinesterase (ChE) monitoring program for agricultural workers who handle toxicity class I or II organophosphate (OP) and Nmethyl- carbamate (CB) pesticides. Washington is only the second state in the union to establish a ChE monitoring program. This poster describes the methodology of a recently initiated cross-sectional study to identify risk factors for ChE depression among pesticide handlers in this monitoring program. Approximately 300 handlers will be recruited for this study. Risk of ChE depression will be evaluated with respect to workplace, behavioral, and genetic characteristics (paraoxonase or PON1 status). A recently developed computer-based survey instrument is being used to collect information about potential OP/CB exposures and other factors that may be related to ChE activity. This survey instrument features audio-recorded questions and icon-based responses that are displayed on a touch screen Tablet PC. The poster also addresses efforts to validate reported exposures through worksite visits for a subset of participants, and analyses of blood specimens for determination of PON1 status for each participant. The overall goal of this study is to characterize potential mechanisms of pesticide overexposure, and determine how such exposures can be prevented among handlers. This study will also provide epidemiologic evidence to determine whether findings from animal-based studies that PON1 status is associated with susceptibility to OP pesticides are consistent in humans. [Description provided by NIOSH]
• Subjects:
  Agriculture Farmers Insecticides Occupational Exposure Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Agricultural Industry Agricultural Safety Farm Workers Genetic Factors Occupational Exposure Pesticides And Agricultural Chemicals Physiological Effects Risk Factors
• Publisher:
  Western Center for Agricultural Health and Safety
• Document Type:
  Text
• Funding:
  Grant ; Cooperative Agreement
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; OSHA Region 10 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  5-6
• NIOSHTIC Number:
  nn:20059773
• Citation:
  Health & safety in Western agriculture: research to practice, September 20-22, 2006, Pacific Grove, California. Davis, CA: Western Center for Agricultural Health and Safety, 2006 Sep; :5-6
• Federal Fiscal Year:
  2006
• Performing Organization:
  University of Washington
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Health & safety in Western agriculture: research to practice, September 20-22, 2006, Pacific Grove, California
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4d660c1e1355e8bb409f6c73dc4ed233fac5df1ac7b52741e4f99a1669644d5a321b486023443ff07e118b7fd27d8420ff08deb86375716a5ac9774533085a5e
• Download URL:
  https://stacks.cdc.gov/view/cdc/223863/cdc_223863_DS1.pdf
• File Type:
  [PDF - 279.24 KB ]