Recombinant Viruses Initiated the Early HIV-1 Epidemic in Burkina Faso

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Fonjungo, Peter N. ; Kalish, Marcia L. ; Schaefer, Amanda ; Rayfield, Mark ; Mika, Jennifer ; Rose, Laura E. ; Heslop, Orville ; Soudré, Robert ; Pieniazek, Danuta
• Description:
  We analyzed genetic diversity and phylogenetic relationships among 124 HIV-1 and 19 HIV-2 strains in sera collected in 1986 from patients of the state hospital in Ouagadougou, Burkina Faso. Phylogenetic analysis of the HIV-1 env gp41 region of 65 sequences characterized 37 (56.9%) as CRF06_cpx strains, 25 (38.5%) as CRF02_AG, 2 (3.1%) as CRF09_cpx, and 1 (1.5%) as subtype A. Similarly, phylogenetic analysis of the protease (PR) gene region of 73 sequences identified 52 (71.2%) as CRF06_cpx, 15 (20.5%) as CRF02_AG, 5 (6.8%) as subtype A, and 1 (1.4%) was a unique strain that clustered along the B/D lineage but basal to the node connecting the two lineages. HIV-2 PR or integrase (INT) groups A (n = 17 [89.5%]) and B (n = 2 [10.5%]) were found in both monotypic (n = 11) and heterotypic HIV-1/HIV-2 (n = 8) infections, with few HIV-2 group B infections. Based on limited available sampling, evidence suggests two recombinant viruses, CRF06_cpx and CRF02_AG, appear to have driven the beginning of the mid-1980s HIV-1 epidemic in Burkina Faso.
• Subjects:
  Genetic Variation HIV-1 HIV-2 HIV Infections Humans Phylogeny
• Source:
  PLoS One. 2014; 9(3).
• Pubmed ID:
  24647246
• Pubmed Central ID:
  PMC3960253
• Document Type:
  Journal Article
• Place as Subject:
  Burkina Faso
• Volume:
  9
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d0263b6910e2faed88c0e50e14c8cca59a98300d585f551fae3958725f7fd7c5
• Download URL:
  https://stacks.cdc.gov/view/cdc/22379/cdc_22379_DS1.pdf
• File Type:
  [PDF - 468.28 KB ]