Chronic Renal Disease Among Lead-Exposed Workers

Details

• Personal Author:
  Barry V ; Steenland, Kyle ; Barry V ; Steenland, Kyle
• Description:
  Background: Very high exposure to inorganic lead causes serious kidney damage. We have studied workers with occupational exposure and data on blood lead. Methods: We extended follow-up for 7 more years, for a previously studied cohort of 58 307 male workers who were part of a surveillance programme in 11 different states. Mortality was assessed using the National Death Index, and end-stage renal disease (ESRD) incidence was assessed using the US Renal Data System. We conducted internal analyses via Cox regression adjusting for age, calendar time and race. Results: The cohort was followed for a median of 18 years and had 524 cases of ESRD and 6527 deaths. Average maximum blood lead was 26 micro g/dL; the mean year of first blood lead test was 1997. No trends by lead level were seen overall or when restricting to those with 15+ years follow-up. Among non-Caucasians with >15 years of follow-up, there was a positive but inconsistent trend (Rate ratios (RRs) 1.00, 2.10, 1.33, 2.20 and 2.76 for maximum blood lead categories of <20 micro g/dL, 20-29 micro g/dL, 30 to <40 micro g/dL, 40 to ≤ 50 micro g/dL and >50 micro g/dL, respectively (p for linear trend 0.26). Those with >15 years of follow-up and birth year <1941 showed a positive trend with increased blood lead (RRs 1.00, 1.14, 1.18, 1.46, 1.66, p trend=0.26). Conclusions: We found no association between higher lead exposure and ESRD. There were positive but not statistically significant trends of increased risk for non-Caucasians with >15 years of follow-up and for older men with >15 years of follow-up. [Description provided by NIOSH]
• Subjects:
  Aging Blood Carcinogens Environmental Exposure Hematologic Tests Lead Men Neoplasms Occupational Health Race Factors Risk Assessment Risk Factors Safety Workplace

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• Keywords:
  Age Groups Blood Analysis Blood Lead Levels Cancer Carcinogenicity Exposure Levels Humans Kidney Damage Kidneys Lead Absorption Lead Compounds Racial Factors Risk Factors Statistical Analysis Work Environment Workers

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• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Georgia ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  415-417
• Volume:
  77
• Issue:
  6
• NIOSHTIC Number:
  nn:20059633
• Citation:
  Occup Environ Med 2020 Jun; 77(6):415-417
• Contact Point Address:
  Dr Kyle Steenland, Environmental Health, Emory University, Atlanta, GA 30322
• Email:
  nsteenl@emory.edu
• CAS Registry Number:
  Lead (CAS RN 7439-92-1) ; Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2020
• Performing Organization:
  Emory University, Atlanta
• Peer Reviewed:
  True
• Start Date:
  20150601
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20190531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:297245cd69c72a05a9ddc3b74760b13f15e86c7fa6fb88ceff95431fd0ba9eb3dafddfc75d3b1a191b819be0c89761a8bd944c54ddbeb85cb622c832bbe7c812
• Download URL:
  https://stacks.cdc.gov/view/cdc/223788/cdc_223788_DS1.pdf
• File Type:
  [PDF - 211.66 KB ]