Yellow Fever Outbreaks in Unvaccinated Populations, Brazil, 2008–2009

Details

• Alternative Title:
  PLoS Negl Trop Dis
• Personal Author:
  Romano, Alessandro Pecego Martins ; Costa, Zouraide Guerra Antunes ; Ramos, Daniel Garkauskas ; Andrade, Maria Auxiliadora ; Jayme, Valéria de Sá ; de Almeida, Marco Antônio Barreto ; Vettorello, Kátia Campomar ; Mascheretti, Melissa ; Flannery, Brendan
• Description:
  Due to the risk of severe vaccine-associated adverse events, yellow fever vaccination in Brazil is only recommended in areas considered at risk for disease. From September 2008 through June 2009, two outbreaks of yellow fever in previously unvaccinated populations resulted in 21 confirmed cases with 9 deaths (case-fatality, 43%) in the southern state of Rio Grande do Sul and 28 cases with 11 deaths (39%) in Sao Paulo state. Epizootic deaths of non-human primates were reported before and during the outbreak. Over 5.5 million doses of yellow fever vaccine were administered in the two most affected states. Vaccine-associated adverse events were associated with six deaths due to acute viscerotropic disease (0.8 deaths per million doses administered) and 45 cases of acute neurotropic disease (5.6 per million doses administered). Yellow fever vaccine recommendations were revised to include areas in Brazil previously not considered at risk for yellow fever.
• Subjects:
  Adolescent Adult Aged Child Child, Preschool Disease Outbreaks Drug-Related Side Effects And Adverse Reactions Female Humans Infant Infant, Newborn Male Middle Aged Vaccination Yellow Fever Yellow Fever Vaccine Young Adult

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• Source:
  PLoS Negl Trop Dis. 2014; 8(3).
• Document Type:
  Journal Article
• Place as Subject:
  Brazil
• Volume:
  8
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ad1782be79514cf319250ae0bc2cb5429f410ab2c3ffce27f7c2cd818459b8c6
• Download URL:
  https://stacks.cdc.gov/view/cdc/22374/cdc_22374_DS1.pdf
• File Type:
  [PDF - 732.28 KB ]