In Utero and Peripubertal Exposure to Phthalates and BPA in Relation to Female Sexual Maturation

Details

• Personal Author:
  Blank-Goldenberg C ; Ferguson KK ; Lee JM ; Meeker JD ; Peterson KE ; Solano-Gonzalez M ; Téllez-Rojo MM ; Watkins DJ
• Description:
  The age of pubertal onset for girls has declined over past decades. Research suggests that endocrine disrupting chemicals (EDCs) may play a role but exposure at multiple stages of development has not been considered. We examined in utero and peripubertal exposure to bisphenol-A (BPA) and phthalates in relation to serum hormones and sexual maturation among females in a Mexico City birth cohort. We measured phthalate metabolite and BPA concentrations in urine collected from mothers during their third trimester (n=116) and from their female children at ages 8-13 years (n=129). Among girls, we measured concurrent serum hormone concentrations, Tanner stages for breast and pubic hair development, and collected information on menarche onset. We used linear and logistic regression to model associations between in utero and peripubertal measures of exposure with hormones and sexual maturation, respectively, controlling for covariates. An interquartile range (IQR) increase in in utero urinary mono-2-ethylhexyl phthalate (MEHP) was positively associated with 29% (95% CI: 9.2-52.6%) higher dehydroepiandrosterone sulfate (DHEA-S), an early indicator of adrenarche, and 5.3 (95% CI: 1.13-24.9) times higher odds of a Tanner stage >1 for pubic hair development. Similar relationships were observed with other in utero but not peripubertal di-2-ethylhexyl phthalate (DEHP) metabolites. IQR increases in in utero monobenzyl phthalate (MBzP) and monoethyl phthalate (MEP) were associated with 29% and 25% higher serum testosterone concentrations (95% CI: 4.3-59.3; 2.1-54.1), respectively. In addition, we observed suggestive associations between in utero and peripubertal MEP concentrations and increased odds of having undergone menarche, and between peripubertal MnBP concentrations and increased odds of having a Tanner stage >1 for both breast and pubic hair development. BPA was not associated with in utero or peripubertal serum hormones or sexual maturation. Our findings suggest in utero phthalate exposure may impact hormone concentrations during peripubescence and timing of sexual maturation. Efforts to control phthalate exposure during pregnancy should be of high priority. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Endocrine System Occupational Health Phthalic Acids Safety Urogenital System
• Keywords:
  Author Keywords: Adrenarche Bisphenol A Cohort Studies Endocrine Disruptors Hormone Activity In Utero Exposure Phthalates Reproductive Effects Sexual Maturation
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  233-241
• Volume:
  134
• NIOSHTIC Number:
  nn:20059508
• Citation:
  Environ Res 2014 Oct; 134:233-241
• Contact Point Address:
  John D. Meeker, Department of Environmental Health Sciences, School of Public Health, University of Michigan, 1835 SPH I, 1415 Washington Heights, Ann Arbor, MI 48109, USA
• Email:
  meekerj@umich.edu
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7)
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a4ce48e969f037d6bb58884b40e8d1d60456035d710b80b3b8c3fee70fe279edc5a68194b1e1eb24525eb44b4ebaf7952a2e85bbfaef330c23e853b7564ef3db
• Download URL:
  https://stacks.cdc.gov/view/cdc/223708/cdc_223708_DS1.pdf
• File Type:
  [PDF - 634.00 KB ]