The Biology of Human Resilience: Opportunities for Enhancing Resilience Across the Life Span

Details

• Personal Author:
  Charney DS ; Feder A ; Fred-Torres S ; Southwick SM
• Description:
  Recent scientific and technological advances have brought us closer to being able to apply a true biopsychosocial approach to the study of resilience in humans. Decades of research have identified a range of psychosocial protective factors in the face of stress and trauma. Progress in resilience research is now advancing our understanding of the biology underlying these protective factors at multiple phenotypic levels, including stress response systems, neural circuitry function, and immune responses, in interaction with genetic factors. It is becoming clear that resilience involves active and unique biological processes that buffer the organism against the impact of stress, not simply involve a reversal of pathological mechanisms. Here, we provide an overview of recent progress in the field, highlighting key psychosocial milestones and accompanying biological changes during development, and into adulthood and old age. Continued advances in our understanding of psychological, social, and biological determinants of resilience will contribute to the development of novel interventions and help optimize the type and timing of intervention for those most at risk, resulting in a possible new framework for enhancing resilience across the life span. [Description provided by NIOSH]
• Subjects:
  Occupational Health Safety
• Keywords:
  Author Keywords: Biopsychosocial Biological Effects Human Interventions Life Span Neurobiology Neurological System Psychological Responses Psychological Stress Psychosocial Factors Resilience

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• ISSN:
  0006-3223
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; New York ; OSHA Region 1 ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  443-453
• Volume:
  86
• Issue:
  6
• NIOSHTIC Number:
  nn:20059336
• Citation:
  Biol Psychiatry 2019 Sep; 86(6):443-453
• Contact Point Address:
  Adriana Feder, M.D., Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1230, New York, NY 10029
• Email:
  adriana.feder@mssm.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  Biological Psychiatry
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ee7b2d570dd1405b5e79baa60ef2b20dfcdb7092a091d4096cd68268ad845660362427141d9b9a17a031ff00f72bda6b78b3a8edaf77afa78f6a875758411e4f
• Download URL:
  https://stacks.cdc.gov/view/cdc/223601/cdc_223601_DS1.pdf
• File Type:
  [PDF - 433.39 KB ]