Ambient Air Pollution as a Mediator in the Pathway Linking Race/Ethnicity to Blood Pressure Elevation: The Multi-Ethnic Study of Atherosclerosis (MESA)

Details

• Personal Author:
  Adar SD ; Guallar E ; Jones MR ; Kaufman JD ; Navas-Acien A ; Post WS ; Smith GS ; Song L
• Description:
  Background: Racial/ethnic disparities in blood pressure and hypertension have been evident in previous studies, as were associations between race/ethnicity with ambient air pollution and those between air pollution with hypertension. The role of air pollution exposure to racial/ethnic differences in hypertension has not been explored. Objective To assess the potential mediating effects of ambient air pollution on the association between race/ethnicity and blood pressure levels. Methods: We studied 6,463 White, Black, Hispanic and Chinese adults enrolled across 6 US cities. Systolic (SBP) and diastolic blood pressure (DBP) were measured at Exam 1 (2000-2002) and Exam 2 (2002-2004). Household-level annual average concentrations of fine particulate matter (PM2.5), oxides of nitrogen (NOX), and ozone (O3) for the year 2000 were estimated for participants. Results: The difference in SBP levels by race/ethnicity that was related to higher PM2.5 concentrations compared with White men ("indirect associations") was 0.3 (95% CI: 0.1, 0.6) mmHg for Black men, 0.3 (95% CI: 0.1, 0.6) mmHg for Hispanic men and 1.0 (95% CI: 0.2, 1.8) mmHg for Chinese men. Findings were similar although not statistically significant for women. PM2.5 did not mediate racial/ethnic differences in DBP. Indirect associations were significant for O3 for SBP among women and men and for DBP among men. In contrast, racial/ethnic disparities were attenuated due to exposure to NOX. Conclusion: Racial disparities in blood pressure were reduced after accounting for PM2.5 and ozone while increased after accounting for NOX. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cardiovascular Diseases Cardiovascular System Environmental Exposure Healthcare Disparities Occupational Health Ozone Race Factors Safety
• Keywords:
  Air Pollution Author Keywords: Air Pollution Blood Pressure Disparities Environmental Exposure Health Disparities Hypertension Nitrogen Oxides Race/Ethnicity Racial Factors
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Michigan ; New York ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 5 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  180
• NIOSHTIC Number:
  nn:20059260
• Citation:
  Environ Res 2020 Jan; 180:108776
• Contact Point Address:
  Miranda R. Jones, Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Office E6137, Baltimore, MD, USA
• Email:
  mjone132@jhu.edu
• CAS Registry Number:
  Nitrogen dioxide (CAS RN 10102-44-0) ; Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9d42d2a884a59966db1077c4f73635a5ebbe38a8352400c4ab6f9ecebab2d568a620a695eb804ce5fa5d6d69221f13ccbaa37763d1b4e3e9c9f1ef6039f155b0
• Download URL:
  https://stacks.cdc.gov/view/cdc/223540/cdc_223540_DS1.pdf
• File Type:
  [PDF - 286.23 KB ]