Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression

Details

• Personal Author:
  Chan AT ; Fuchs CS ; Giannakis M ; Giovannucci E ; Gu M ; Hamada T ; Kim SA ; Kosumi K ; Liu L ; Ma Y ; Meyerhardt JA ; Morikawa T ; Nevo D ; Nishihara R ; Nowak JA ; Ogino S ; Papantoniou K ; Schernhammer ES ; Shi Y ; Song M ; Sui J ; Wang M ; Wu K ; Zhang X
• Description:
  Background: We hypothesized that the risk of colorectal cancer in night-shift workers might be different according to insulin receptor substrate status. Methods: Among 77,470 eligible women having night work assessed in the Nurses' Health Study, we documented a total of 1,397 colorectal cancer cases, of which 304 or 308 had available data on IRS1 and IRS2, respectively. We used duplication-method Cox proportional hazards regression analysis for competing risks to calculate HRs and 95% confidence intervals (CI) for each colorectal cancer subtype. We measured tumor IRS1 or IRS2 expression by immunohistochemistry (IHC). Results: Compared with women who never worked night shifts, those working >/=15 years night shifts had a marginal trend of increased overall risk of colorectal cancer (Ptrend = 0.06; multivariable HR = 1.20; 95% CI, 0.99-1.45). Longer duration of night-shift work was associated with a higher risk of IRS2-positive tumors (multivariable HR = 2.69; 95% CI, 1.48-4.89; Ptrend = 0.001, >/=15 years night shifts vs. never) but not with IRS2-negative tumors (multivariable HR = 0.90; 95% CI, 0.54-1.51; Ptrend = 0.72; Pheterogeneity for IRS2 = 0.008). Similarly, the corresponding multivariable HRs were 1.81 for IRS1-positive tumors (95% CI, 0.94-3.48; Ptrend = 0.06) and 1.13 for IRS1-negative tumors (95% CI, 0.71-1.80; Ptrend = 0.56; Pheterogeneity for IRS1 = 0.02). Conclusions: Our molecular pathologic epidemiology data suggest a potential role of IRS in mediating carcinogenesis induced by night-shift work. Impact: Although these findings need validation, rotating night shift might increase colorectal cancer risk in women with abnormal insulin receptor pathways. [Description provided by NIOSH]
• Subjects:
  Circadian Rhythm Health Personnel Neoplasms Occupational Health Safety Shift Work Schedule Women
• Keywords:
  Biological Rhythms Cancer Rates Circadian Rhythms Colorectal Cancer Nurses Nursing Shift Work Work Schedules
• ISSN:
  1055-9965
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; Maryland ; Massachusetts ; OSHA Region 1 ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  133-140
• Volume:
  29
• Issue:
  1
• NIOSHTIC Number:
  nn:20059254
• Citation:
  Cancer Epidemiol Biomark Prev 2020 Jan; 29(1):133-140
• Contact Point Address:
  Xuehong Zhang, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115
• Email:
  xuehong.zhang@channing.harvard.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  Brigham and Women's Hospital, Inc., Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  20100801
• Source Full Name:
  Cancer Epidemiology, Biomarkers & Prevention
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2726aa0eebcd1ffdfca9ade1a06ef7f0eeea4aba8cba453ad6d0c4dd7a8e967931f9d8592631153a7190f60688b45b7ab769c7ded5a8ec7509193a01ea8bbd14
• Download URL:
  https://stacks.cdc.gov/view/cdc/223534/cdc_223534_DS1.pdf
• File Type:
  [PDF - 359.34 KB ]