Stress as a Potential Modifier of the Impact of Lead Levels on Blood Pressure: The Normative Aging Study

Details

• Personal Author:
  Hu H ; Kubzansky L ; McNeely E ; Nie H ; Peters JL ; Schwartz J ; Sparrow D ; Spiro A III ; Wright RO
• Description:
  Background: Lead exposure and psychological stress have been independently associated with hypertension in various populations, and animal studies suggest that when they co-occur, their effects may be exacerbated. Objectives: We examined whether psychological stress modifies the impact of cumulative lead exposure (measured as bone lead levels) on hypertension and blood pressure in Boston-area community-exposed men participating in the Normative Aging Study. Methods: We evaluated the modifying effect of stress on lead exposure on baseline hypertension status (513 participants) and on blood pressure in those without hypertension (237 participants), cross-sectionally. In baseline nonhypertensives, we examined the same risk factors in relation to prospective risk of developing hypertension. Results: Cross-sectional analysis revealed a positive interaction between stress and tibia lead on systolic blood pressure, after adjusting for age, body mass index, family history of high blood pressure, education, smoking, alcohol consumption, physical activity, and nutritional factors. In prospective multivariate analyses, high stress also modified the effect of tibia lead and patella lead on the risk of developing hypertension. Those reporting high stress had 2.66 [95% confidence interval (CI), 1.43-4.95] times the risk of developing hypertension per standard deviation increase in tibia lead and had 2.64 (95% CI, 1.42-4.92) times the risk per standard deviation increase in patella lead. Conclusion: To our knowledge, these are the first analyses to look at interactive effects of stress and lead on hypertension in humans. These results suggest that the effect of lead on hypertension is most pronounced among highly stressed individuals, independent of demographic and behavioral risk factors. [Description provided by NIOSH]
• Subjects:
  Alcoholic Beverages Animals Cardiovascular Diseases Cardiovascular System Education Environmental Exposure Laboratories Lead Men Occupational Health Risk Assessment Risk Factors Safety Smokers Women

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• Keywords:
  Alcohol Author Keywords: Blood Pressure Blood Lead Levels Blood Pressure Bone Disorders Bone Lead Exposure Levels Humans Hypertension Laboratory Animals Nutrition Physical Exercise Psychosocial Factors Psychosocial Stress Risk Factors Smoking Statistical Analysis Stress Systolic Pressure

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• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  115
• Issue:
  8
• NIOSHTIC Number:
  nn:20059189
• Citation:
  Environ Health Perspect 2007 Aug; 115(8):1154-1159
• Contact Point Address:
  Junenette L. Peters, Department of Environmental Health, Harvard School of Public Health, P.O. Box 15697, Landmark Ctr. East/Rm 3-111-23, 401 Park Dr., Boston, MA 02215
• Email:
  jpeters@hsph.harvard.edu
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6715d0a8fd79fadc322e653d8ac10257113a84b3d2eee12ac9d7227f6370a79a98b628697026b4dbce99bba899c407775be9375a5e5cd35d5e472f9213fd3c1e
• Download URL:
  https://stacks.cdc.gov/view/cdc/223483/cdc_223483_DS1.pdf
• File Type:
  [PDF - 157.10 KB ]