Antimullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women’s Health Across the Nation

Details

• Personal Author:
  Burnett-Bowie S-AM ; Darakananda K ; Donahoe PK ; Finkelstein JS ; Greendale GA ; Harlow SD ; Joffe H ; Karlamangla A ; Kumar A ; Lee H ; Martin DE ; McConnell D ; Merrilat S ; Morrison A ; Neer RM ; Pastore LM ; Prizand SH ; Randolph JF Jr. ; Santoro N ; Sluss PM
• Description:
  Background: A test that helps predict the time to the final menstrual period (FMP) has been sought for many years. Objective: To assess the ability of antimullerian hormone (AMH) measurements to predictions the time to FMP. Design: Prospective longitudinal cohort study. Setting: The Study of Women's Health Across the Nation. Participants and Measurements: AMH and FSH were measured in 1537 pre- or early perimenopausal women, mean age 47.5 +/- 2.6 years at baseline, then serially until 12 months of amenorrhea occurred. AMH was measured using a 2-site ELISA with a detection limit of 1.85 pg/mL. Main Outcome Measure: Areas under the receiver operating curves (AUC) for AMH-based and FSH-based predictions of time to FMP, stratified by age. Probabilities that women would undergo their FMP in the next 12, 24, or 36 months across a range of AMH values were assessed. Results: AUCs for predicting that the FMP will occur within the next 24 months were significantly greater for AMH-based than FSH-based models. The probability that a woman with an AMH <10 pg/mL would undergo her FMP within the next 12 months ranged from 51% at h<48 years of age to 79% at >/=51 years. The probability that a woman with an AMH >100 pg/mL would not undergo her FMP within the next 12 months ranged from 97% in women <48 years old to 90% in women >/=51 years old. Conclusions: AMH measurement helps estimate when a woman will undergo her FMP, and, in general, does so better than FSH. [Description provided by NIOSH]
• Subjects:
  Age Factors Cohort Studies Endocrine System Occupational Health Safety Urogenital System Women
• Keywords:
  Age Factors Aging Author Keywords: Female Reproductive Endocrinology Cohort Studies Endocrinology Gonadotropins Hormone Activity Hormones Humans Inhibin/Activin/Follistatin/AMH Longitudinal Study Menopause Ovaries Reproductive System

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• ISSN:
  0021-972X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; Massachusetts ; Michigan ; New York ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 8 ; OSHA Region 9 ; Pennsylvania ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  105
• Issue:
  4
• NIOSHTIC Number:
  nn:20059117
• Citation:
  J Clin Endocrinol Metab 2020 Apr; 105(4):e1862-e1871
• Contact Point Address:
  Joel S. Finkelstein, MD, Harvard Medical School, Endocrine Unit, Tier 1051, Massachusetts General Hospital, 50 Blossom St, Boston, MA 02114
• Email:
  jfinkelstein@partners.org
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Clinical Endocrinology and Metabolism
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b04daad4a01589569fafd67f69d5dca7e05d6eca9c77d59a36527ee7534f83bc77d0d0c35bb45cfa138484e9c31cb3a2679ed953eac94af114e56a581eccceef
• Download URL:
  https://stacks.cdc.gov/view/cdc/223431/cdc_223431_DS1.pdf
• File Type:
  [PDF - 180.51 KB ]