Urushiol Compounds Detected in Toxicodendron-Labeled Consumer Products Using Mass Spectrometry

Details

• Personal Author:
  Aschenbeck KA ; B'Hymer, Clayton ; Hylwa SA ; Law, Brandon F. ; Siegel, Paul D. ; Zhang AJ
• Description:
  Background: Urushiol, the culprit allergen in Toxicodendron plants such as poison ivy, is an oily mixture of 15 and 17 carbon side chain alk-(en)-yl catechols. Recently, consumer products have been identified that contain Toxicodendron as an ingredient on their label; however, no studies have assessed whether urushiol is indeed present within these products. Objective: The aim of the study was to determine whether urushiol compounds are present in consumer products labeled as containing Toxicodendron species. Methods: Gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry were performed on 9 consumer products labeled as containing Toxicodendron species, including topical homeopathic remedies. Single ion monitoring gas chromatography-mass spectrometry was programmed in selective ion mode to detect 3-methylcatechol characteristic fragment ions of alk-(en)-yl catechols after silanization. Similarly, single ion monitoring liquid chromatography-tandem mass spectrometry was programmed to detect 4 urushiol pentadecylcatechols and 5 urushiol heptadecylcatechols using previously reported mass-to-charge ratios. Results: Gas chromatography-mass spectrometry detected alk-(en)-yl catechols in 67% (6/9) of the products tested. Liquid chromatography-tandem mass spectrometry detected multiple urushiol pentadecylcatechols and heptadecylcatechols in 44% (4/9) of the products tested. Conclusions: Alk-(en)-yl catechols and multiple urushiols were detected in consumer products listing Toxicodendron species as an ingredient. Clinicians should be aware of these known allergenic ingredients in consumer products. Description provided by NIOSH
• Subjects:
  • Hypersensitivity
  • Occupational Health
  • Safety
• Keywords:
  • Allergens
  • Mass spectrometry
  • Toxic effects
  • Carbon
  • Liquid chromatography
  • Statistical analysis
  • Organic compounds
  • Organic chemicals
• ISSN:
  1710-3568
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  134-139
• Volume:
  31
• Issue:
  2
• NIOSHTIC Number:
  nn:20059110
• Citation:
  Dermatitis 2020 Mar/Apr; 31(2):134-139
• Contact Point Address:
  Amy J. Zhang, MD, 7550 34th Ave S, #10I, Minneapolis, MN 55450
• Email:
  fengx358@umn.edu
• Federal Fiscal Year:
  2020
• Peer Reviewed:
  True
• Source Full Name:
  Dermatitis
• Download URL:
  https://stacks.cdc.gov/view/cdc/223425/cdc_223425_DS1.pdf
• File Type:
  [PDF - 570.15 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3284c51b18eb426dbc6eedb7b6185d6b93c5a137ed957b498454b06d509810ff59c7bdee2e9f4e4c183612d94b3967732f8f3d43da7b3058e374fd9d804e26f6