Urushiol Compounds Detected in Toxicodendron-Labeled Consumer Products Using Mass Spectrometry

Details

• Personal Author:
  Aschenbeck KA ; B'Hymer, Clayton ; Hylwa SA ; Law, Brandon F. ; Siegel, Paul D. ; Zhang AJ
• Description:
  Background: Urushiol, the culprit allergen in Toxicodendron plants such as poison ivy, is an oily mixture of 15 and 17 carbon side chain alk-(en)-yl catechols. Recently, consumer products have been identified that contain Toxicodendron as an ingredient on their label; however, no studies have assessed whether urushiol is indeed present within these products. Objective: The aim of the study was to determine whether urushiol compounds are present in consumer products labeled as containing Toxicodendron species. Methods: Gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry were performed on 9 consumer products labeled as containing Toxicodendron species, including topical homeopathic remedies. Single ion monitoring gas chromatography-mass spectrometry was programmed in selective ion mode to detect 3-methylcatechol characteristic fragment ions of alk-(en)-yl catechols after silanization. Similarly, single ion monitoring liquid chromatography-tandem mass spectrometry was programmed to detect 4 urushiol pentadecylcatechols and 5 urushiol heptadecylcatechols using previously reported mass-to-charge ratios. Results: Gas chromatography-mass spectrometry detected alk-(en)-yl catechols in 67% (6/9) of the products tested. Liquid chromatography-tandem mass spectrometry detected multiple urushiol pentadecylcatechols and heptadecylcatechols in 44% (4/9) of the products tested. Conclusions: Alk-(en)-yl catechols and multiple urushiols were detected in consumer products listing Toxicodendron species as an ingredient. Clinicians should be aware of these known allergenic ingredients in consumer products. [Description provided by NIOSH]
• Subjects:
  Hypersensitivity Occupational Health Safety
• Keywords:
  Allergens Carbon Liquid Chromatography Mass Spectrometry Organic Chemicals Organic Compounds Statistical Analysis Toxic Effects
• ISSN:
  1710-3568
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  134-139
• Volume:
  31
• Issue:
  2
• NIOSHTIC Number:
  nn:20059110
• Citation:
  Dermatitis 2020 Mar/Apr; 31(2):134-139
• Contact Point Address:
  Amy J. Zhang, MD, 7550 34th Ave S, #10I, Minneapolis, MN 55450
• Email:
  fengx358@umn.edu
• Federal Fiscal Year:
  2020
• Peer Reviewed:
  True
• Source Full Name:
  Dermatitis
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3284c51b18eb426dbc6eedb7b6185d6b93c5a137ed957b498454b06d509810ff59c7bdee2e9f4e4c183612d94b3967732f8f3d43da7b3058e374fd9d804e26f6
• Download URL:
  https://stacks.cdc.gov/view/cdc/223425/cdc_223425_DS1.pdf
• File Type:
  [PDF - 570.15 KB ]