Prediagnostic Adult Body Mass Index Change and Esophageal Adenocarcinoma Survival

Details

• Personal Author:
  Betensky RA ; Christiani, David C. ; Giovannucci EL ; Loehrer EA ; Shafer A
• Description:
  Background: We examined whether body mass index (BMI) changes in adulthood, prior to disease onset, are associated with overall survival among esophageal adenocarcinoma patients. Methods: We included 285 histologically confirmed patients with a complete baseline BMI questionnaire. Using extended Cox regression models, we obtained adjusted hazard ratios (HRs) for the associations between overall survival and BMI at diagnosis, BMI 6 months before diagnosis, self-reported average adult BMI, and deltaBMI (BMI 6 months before diagnosis minus average adult BMI), categorized into tertiles <0 kg/m2 (BMI loss), >/=0 and <1.25 kg/m2 (stable BMI), and >/=1.25 kg/m2 (BMI gain). We also assessed interaction between deltaBMI and average adult BMI (>/= kg/m2 versus <27.5 kg/m2) with overall survival. Results: Body mass index at diagnosis >25 and <35 kg/m2 was associated with better overall survival. Compared to patients with stable BMI in adulthood, patients who gained BMI throughout adulthood had 1.68 times the all-cause hazard of death (95% CI: 1.17-2.43; P < .01), independent of diagnosis BMI and percent weight loss 6 months before diagnosis. Compared to patients with average adult BMI < 27.5 who maintained stable adult BMI, patients with average adult BMI >/= 27.5 kg/m2 who gained BMI had the worst survival (HR = 3.05; 95% CI 1.62-5.72; P < .01). Conclusion: Body mass index gain in adulthood is associated with poor overall survival, and maintaining a normal body weight throughout adulthood is associated with the best overall survival among esophageal adenocarcinoma patients, independent of BMI at diagnosis. [Description provided by NIOSH]
• Subjects:
  Body Weight Neoplasms Occupational Health Safety
• Keywords:
  Author Keywords: Adenocarcinoma BMI Body Mass Index Body Weight Body Weight Changes Carcinomas Esophageal Neoplasms Survival Analysis Survival Rate
• ISSN:
  2045-7634
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  9
• Issue:
  10
• NIOSHTIC Number:
  nn:20059052
• Citation:
  Cancer Med 2020 May; 9(10):3613-3622
• Contact Point Address:
  Elizabeth A. Loehrer, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
• Email:
  eal405@mail.harvard.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Cancer Medicine
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e216a649ce6112272ea16b0897f878b913775d53b67f59e206477e1b707295692ee9a4c77896691b7e0f0c27e47d5edaa29fb3f25438fbf60a4312db01f80e58
• Download URL:
  https://stacks.cdc.gov/view/cdc/223379/cdc_223379_DS1.pdf
• File Type:
  [PDF - 331.25 KB ]