Dermal Exposure to M-Xylene Leads to Increasing Oxidative Species and Low Molecular Weight DNA Levels in Rat Skin

Details

• Personal Author:
  Garrett CM ; Gunasekar PG ; McDougal JN ; Rogers JV
• Description:
  Dermal absorption of organic solvents, such as m-xylene, can lead to skin inflammation and pathological changes within hours after exposure. This study detected oxidative species formation and low molecular weight (LMW) DNA in rat skin as potential indicators of m-xylene-induced skin injury. At 0, 1, 2, 4, and 6 h after the beginning of a 1-h exposure, skin samples were removed and analyzed for oxidative species formation and LMW DNA analysis. At 2 h, mean oxidative species levels increased significantly (P < 0.05) above unexposed samples. Significantly higher (P < 0.05) LMW DNA values were observed at 2, 4, and 6 h compared to unexposed controls. These results show that oxidative species formation and LMW DNA levels in the skin may serve as indicators for predicting safe exposure levels to m-xylene and other volatile organic solvents. [Description provided by NIOSH]
• Subjects:
  Animals Occupational Health Safety Skin Solvents Volatile Organic Compounds
• Keywords:
  Animal Studies Author Keywords: M-Xylene Dermal Exposures M-Xylene Organic Solvents Oxidative Species Skin Exposure VOCs Volatile Organic Compounds
• ISSN:
  1095-6670
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  228-230
• Volume:
  15
• Issue:
  4
• NIOSHTIC Number:
  nn:20058801
• Citation:
  J Biochem Mol Toxicol 2001 Jul; 15(4):228-230
• Contact Point Address:
  James N. McDougal, Geo-Centers, Inc., 2856 G. Street (AFRL/HEST), Wright-Patterson Air Force Base, OH 45433, US
• Email:
  james.mcdougal@wright.edu
• CAS Registry Number:
  m-Xylene (CAS RN 108-38-3)
• Federal Fiscal Year:
  2001
• Performing Organization:
  Wright State University, Dayton, Ohio
• Peer Reviewed:
  False
• Start Date:
  19980930
• Source Full Name:
  Journal of Biochemical and Molecular Toxicology
• End Date:
  20020929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8e396ede00917d49e3aa186b13003029c54b2969f436f01416a35da1bc55e9ea8f8c4353460c58fab9bf0509a96effaa002a3645651a845f121f154de551963a
• Download URL:
  https://stacks.cdc.gov/view/cdc/223197/cdc_223197_DS1.pdf
• File Type:
  [PDF - 177.29 KB ]