Estimating Minute Ventilation and Air Pollution Inhaled Dose Using Heart Rate, Breath Frequency, Age, Sex and Forced Vital Capacity: A Pooled-Data Analysis

Details

• Personal Author:
  Dons E ; Giles L ; Good N ; Greenwald R ; Hayat MJ ; Jakovljevic DG ; Villar R
• Description:
  Air pollution inhaled dose is the product of pollutant concentration and minute ventilation (VE). Previous studies have parameterized the relationship between VE and variables such as heart rate (HR) and have observed substantial inter-subject variability. In this paper, we evaluate a method to estimate VE with easy-to-measure variables in an analysis of pooled-data from eight independent studies. We compiled a large diverse data set that is balanced with respect to age, sex and fitness level. We used linear mixed models to estimate VE with HR, breath frequency (fB), age, sex, height, and forced vital capacity (FVC) as predictors. FVC was estimated using the Global Lung Function Initiative method. We log-transformed the dependent and independent variables to produce a model in the form of a power function and assessed model performance using a ten-fold cross-validation procedure. The best performing model using HR as the only field-measured parameter was VE = e-9.59HR2.39age0.274sex-0.204FVC0.520 with HR in beats per minute, age in years, sex is 1 for males and 2 for females, FVC in liters, and a median(IQR) cross-validated percent error of 0.664(45.4)%. The best performing model overall was VE = e-8.57HR1.72fB0.611age0.298sex-0.206FVC0.614, where fB is breaths per minute, and a median (IQR) percent error of 1.20(37.9)%. The performance of these models is substantially better than any previously-published model when evaluated using this large pooled-data set. We did not observe an independent effect of height on VE, nor an effect of race, though this may have been due to insufficient numbers of non-white participants. We did observe an effect of FVC such that these models over- or under-predict VE in persons whose measured FVC was substantially lower or higher than estimated FVC, respectively. Although additional measurements are necessary to confirm this finding regarding FVC, we recommend using measured FVC when possible. [Description provided by NIOSH]
• Subjects:
  Age Factors Air Pollution Body Height Cardiovascular System Environmental Exposure Lung Occupational Health Respiratory System Safety Sex Characteristics Ventilation

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• Keywords:
  Age Factors Air Pollution Analytical Methods Breathing Data Processing Exposure Levels Heart Rate Height Factors Humans Inhalation Lung Function Mathematical Models Models Performance Tests Physical Fitness Physiological Measurements Pollutants Pollution Pulmonary Function Sex Factors Vital Capacity

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• ISSN:
  1932-6203
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Georgia ; OSHA Region 4 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• Issue:
  7
• NIOSHTIC Number:
  nn:20058717
• Citation:
  PLoS One 2019 Jul; 14(7):e0218673
• Contact Point Address:
  Roby Greenwald, Division of Environmental Health, School of Public Health, Georgia State University, Atlanta, Georgia, United States of America
• Email:
  rgreenwald@gsu.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Colorado, Denver
• Peer Reviewed:
  True
• Start Date:
  20070701
• Source Full Name:
  PLoS One
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e5fea92006f6c3d1486cf59ce30149fcd158c5fa036548162a836791a4b1a3b3c59bb43916f49957e339a0e52a5e00422752e33a44d572f7675c720e3436001b
• Download URL:
  https://stacks.cdc.gov/view/cdc/223118/cdc_223118_DS1.pdf
• File Type:
  [PDF - 1.33 MB ]