Associations Between Shiftwork and Biomarkers of Subclinical Cardiovascular Disease: The BCOPS Study

Details

• Personal Author:
  Andrew, Michael E. ; Charles LE ; Fekedulegn D ; Hartley TA ; Mnatsakanova A ; Tinney-Zara CA ; Violanti JM
• Description:
  Purpose: Police officers work shift schedules and are known to have a higher prevalence of cardiovascular disease (CVD) compared to the general population. Our objective was to investigate associations between shiftwork and select subclinical CVD biomarkers. Methods: Participants were officers examined in the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) study during 2004-2009. Daily electronic payroll records from the City of Buffalo, NY were used to assess dominant shift schedule as day, afternoon, or night. Dominant shift was the shift on which the highest percentage of hours was worked. Fasting blood specimens were collected and analyzed for white blood cell count (WBC), C-reactive protein (hsCRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNFa) using a standard protocol. Analysis of variance/covariance were used to examine mean levels of all biomarkers across categories of shiftwork. Results were adjusted for age, sex, race/ethnicity, smoking status, body mass index (BMI), total cholesterol, HDL cholesterol, and triglycerides. Results: The mean age of officers (n=360; 74% male) was 41.4 years (SD=6.4); 50.3% worked day shift and 22.8% night shift. Among men only, officers on night shift had significantly higher mean WBC count compared with those on day shift [5.90x109/L (95% CI=5.62-6.19) vs. 5.45x109/L (5.23-5.67)]; p=0.017. Among officers with BMI >/=25 kg/m2, those on afternoon shift had significantly higher mean levels of IL-6 compared with those on day shift [2.01 ng/mL (1.77-2.27) vs. 1.54 ng/mL (1.39-1.71); p=0.002]. Also, officers on night shift had significantly higher mean levels of TNFa compared with those on day shift [5.23 pg/mL (4.80-5.70) vs. 4.52 pg/mL (4.25-4.81)]; p=0.010. Shiftwork was not significantly associated with hsCRP. Conclusion: The higher WBC count, IL-6, and TNFa observed among officers working afternoon and night shifts may indicate that they are at increased risk for developing CVD. Further research is warranted. [Description provided by NIOSH]
• Subjects:
  Biomarkers Blood Cardiovascular Diseases Cardiovascular System Hematologic Tests Law Enforcement Occupational Health Safety Shift Work Schedule
• Keywords:
  Biological Effects Blood Analysis Cardiovascular Disease Cross Sectional Studies Law Enforcement Workers Police Officers Shift Work
• ISSN:
  1047-2797
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  27
• Issue:
  8
• NIOSHTIC Number:
  nn:20064624
• Citation:
  Ann Epidemiol 2017 Aug; 27(8):528
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Public Safety
• Performing Organization:
  State University of New York at Buffalo
• Peer Reviewed:
  False
• Start Date:
  20150901
• Source Full Name:
  Annals of Epidemiology
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2eb160f5c811aa5c241576b07d758dec26166e6fb8ff463ecb72191c4d153168a7c6c5c58f8d4a8345fe7cf1521264672e25d389400a49af80774b05176efc68
• Download URL:
  https://stacks.cdc.gov/view/cdc/223054/cdc_223054_DS1.pdf
• File Type:
  [PDF - 133.82 KB ]