The Association of Bone and Blood Manganese with Motor Function in Chinese Workers

Details

• Personal Author:
  Fan Q ; Li Y ; Liu Y ; Mostafaei F ; Nie LH ; Rolle-McFarland D ; Wells EM ; Zauber SE ; Zheng W ; Zhou Y
• Description:
  Manganese (Mn) is an essential element. However, Mn overexposure is associated with motor dysfunction. This cross-sectional study assessed the association between bone Mn (BnMn) and whole blood Mn (BMn) with motor function in 59 Chinese workers. BnMn and BMn were measured using a transportable in vivo neutron activation analysis system and inductively coupled plasma mass spectrometry, respectively. Motor function (manual coordination, postural sway, postural hand tremor, and fine motor function) was assessed using the Coordination Ability Test System (CATSYS) and the Purdue Pegboard. Relationships between Mn biomarkers and motor test scores were analyzed with linear regression models adjusted for age, education, current employment, and current alcohol consumption. BMn was significantly inversely associated with hand tremor intensity (dominant hand (beta=-0.04, 95 % confidence interval (CI):-0.07, -0.01; non-dominant hand beta=-0.05, 95 % CI:-0.08, -0.01) hand tremor center frequency (non-dominant hand beta=-1.61, 95 % CI:-3.03, -0.19) and positively associated with the Purdue Pegboard Assembly Score (beta = 4.58, 95 % CI:1.08, 8.07). BnMn was significantly inversely associated with finger-tapping performance (non-dominant hand beta=-0.02, 95 % CI:-0.04,-0.004), mean sway (eyes closed and foam beta=-0.68, 95 % CI:-1.31,-0.04), and positively associated with hand tremor center frequency (dominant hand, beta = 0.40, 95 % CI:0.002, 0.80). These results suggest BMn is related to better postural hand tremor and fine motor control and BnMn is related to worse motor coordination and postural hand tremor but better (i.e., less) postural sway. The unexpected positive results might be explained by choice of biomarker or confounding by work-related motor activities. Larger, longitudinal studies in this area are recommended. [Description provided by NIOSH]
• Subjects:
  Biomarkers Manganese Musculoskeletal System Nervous System Occupational Exposure Occupational Health Safety
• Keywords:
  Author Keywords: Manganese Cross Sectional Studies IVNAA Metal Workers Motor Skills Movement Disorders Neuromotor Function Neurophysiological Effects Neurotoxic Effects Neurotoxicity Occupational Exposure Posture

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• ISSN:
  0161-813X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; Georgia ; Indiana ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  224-230
• Volume:
  88
• NIOSHTIC Number:
  nn:20064604
• Citation:
  Neurotoxicology 2022 Jan; 88:224-230
• Contact Point Address:
  Ellen M. Wells, 550 Stadium Mall Drive, West Lafayette, IN, 47907, USA
• Email:
  wells54@purdue.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2022
• Performing Organization:
  Purdue University, West Lafayette, Indiana
• Peer Reviewed:
  True
• Start Date:
  20140901
• Source Full Name:
  Neurotoxicology
• End Date:
  20170831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:722fb7051d13b8b15f20044c343e964e35d959fb744b9d05cedb39c3865373790c086296aab2c57c6e82abaaa77c4d103436d3238f49e7d8124dd9f07db9da5a
• Download URL:
  https://stacks.cdc.gov/view/cdc/223038/cdc_223038_DS1.pdf
• File Type:
  [PDF - 472.34 KB ]