Smoking-Associated Risks of Conventional Adenomas and Serrated Polyps in the Colorectum

Details

• Personal Author:
  Ahnen DJ ; Baron JA ; Bresalier RS ; Burke CA ; Church JM ; Church, Timothy R. ; Crockett SD ; Figueiredo JC ; McKeown-Eyssen G ; Morris CB ; Robertson DJ ; Sandler RS ; Snover DC
• Description:
  Purpose: Prior studies suggest cigarette smoking is associated with 1.5- to twofold increased risk of colorectal adenomas and possibly a higher risk of serrated polyps. Further clarification of risk differences between adenomas and serrated polyps is needed with regard to co-occurrence and polyp location. Methods: We conducted a combined analysis of conventional adenoma and serrated polyp occurrence using individual-level data from 2,915 patients participating in three colonoscopy-based clinical trials. All participants had >/=1 adenomas removed at baseline and were followed for up to 4 years. Smoking habits and other lifestyle factors were collected at baseline using questionnaires. We used generalized linear regression to estimate risk ratios and 95 % confidence intervals. Results: Smokers were at slightly increased risk of adenomas compared to never smokers [current: RR 1.29 (95 % CI 1.11-1.49) and former: RR 1.18 (1.05-1.32)]. Smoking was associated with greater risk of serrated polyps [current: RR 2.01 (1.66-2.44); former: RR 1.42 (1.20-1.68)], particularly in the left colorectum. Associations between current smoking and occurrence of serrated polyps only [RR 2.33 (1.76-3.07)] and both adenomas and serrated polyps [RR 2.27 (1.68-3.06)] were more pronounced than for adenomas only [RR 1.31 (1.08-1.58)]. Results were similar for other smoking variables and did not differ by gender or for advanced adenomas. Conclusions: Cigarette smoking has only a weak association with adenomas, but is associated with a significantly increased risk of serrated polyps, particularly in the left colorectum. Since a minority of left-sided serrated polyps is thought to have malignant potential, the role of smoking in initiation phases of carcinogenesis is uncertain. [Description provided by NIOSH]
• Subjects:
  Carcinogens Digestive System Digestive System Diseases Epidemiology Occupational Health Safety Smoke Smokers Tobacco Products
• Keywords:
  Adenomas Author Keywords: Smoking Carcinogenesis Cigarette Smoking Colorectal Colorectal Cancer Gastrointestinal System Disorders Intestinal Cancer Serrated Polyps Tobacco Tobacco Smoke

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• ISSN:
  0957-5243
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; Minnesota ; New Hampshire ; North Carolina ; Ohio ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 8 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  377-386
• Volume:
  26
• Issue:
  3
• NIOSHTIC Number:
  nn:20064572
• Citation:
  Cancer Causes Control 2015 Mar; 26(3):377-386
• Contact Point Address:
  J. C. Figueiredo, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
• Email:
  anefigu@usc.edu
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Minnesota Twin Cities
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Cancer Causes and Control
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4d40e128b59fe6c028ab843cab256b38f2d6ace1ed76f975b59cb92979bd5ddd8039b1927386a48f22f6e6f1202a6bf1a4cf5e3ce5f050c3efdd604a8c878108
• Download URL:
  https://stacks.cdc.gov/view/cdc/223010/cdc_223010_DS1.pdf
• File Type:
  [PDF - 200.35 KB ]