How Tetraspanin-Mediated Cell Entry of SARS-CoV-2 Can Dysregulate the Shedding of the ACE2 Receptor by ADAM17

Details

• Personal Author:
  Healy EF
• Description:
  COVID-19, the respiratory infection caused by the novel coronavirus SARS-CoV-2, presents a clinical picture consistent with the dysregulation of many of the pathways mediated by the metalloprotease ADAM17. ADAM17 is a sheddase that plays a key role in the modulation of ACE2, the receptor which also functions as the point of attachment leading to cell entry by the virus. This work investigates the possibility that ADAM17 dysregulation and attachment of the SARS-CoV-2 virion to the ACE2 receptor are linked events, with the latter causing the former. Tetraspanins, the transmembrane proteins that function as scaffolds for the construction of viral entry platforms, are mooted as key components in this connection. [Description provided by NIOSH]
• Subjects:
  Communicable Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Viral Diseases
• Keywords:
  ACE2 ADAM17 Author Keywords: COVID-19 CD9 Cell Signaling Cellular Function Coronavirus COVID-19 Proteins Respiratory Infections SARS-CoV-2 Tetraspanin Viral Diseases Viral Infections

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• ISSN:
  0006-291X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  52-56
• Volume:
  593
• NIOSHTIC Number:
  nn:20064558
• Citation:
  Biochem Biophys Res Commun 2022 Feb; 593:52-56
• Contact Point Address:
  Eamonn F Healy, Department of Chemistry, St. Edward's University, Austin, TX, 78704
• Email:
  healy@stedwards.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  Mount Sinai School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Biochemical and Biophysical Research Communications
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7949d7aec4eb4344768cb8fcdd1abc651c0d5d6ea119cfa58aaa0b3d3b997615857169b99d99dd0dc288a2a4640b12c624edf048916d79804e3b7ddb18a98ea7
• Download URL:
  https://stacks.cdc.gov/view/cdc/222998/cdc_222998_DS1.pdf
• File Type:
  [PDF - 1.47 MB ]