Longitudinal Impact of WTC Dust Inhalation on Rat Cardiac Tissue Transcriptomic Profiles

Details

• Personal Author:
  Chen L-C ; Cohen MD ; Costa M ; Gorr MW ; Horton L ; Kluz T ; Lee H-W ; Lu Y ; Park S-H ; Prophete C ; Shao Y ; Sisco M ; Sun H ; Wold LE ; Zelikoff J
• Description:
  First responders (FR) exposed to the World Trade Center (WTC) Ground Zero air over the first week after the 9/11 disaster have an increased heart disease incidence compared to unexposed FR and the general population. To test if WTC dusts were causative agents, rats were exposed to WTC dusts (under isoflurane [ISO] anesthesia) 2 h/day on 2 consecutive days; controls received air/ISO or air only. Hearts were collected 1, 30, 240, and 360 d post-exposure, left ventricle total RNA was extracted, and transcription profiles were obtained. The data showed that differentially expressed genes (DEG) for WTC vs. ISO rats did not reach any significance with a false discovery rate (FDR) < 0.05 at days 1, 30, and 240, indicating that the dusts did not impart effects beyond any from ISO. However, at day 360, 14 DEG with a low FDR were identified, reflecting potential long-term effects from WTC dust alone, and the majority of these DEG have been implicated as having an impact on heart functions. Furthermore, the functional gene set enrichment analysis (GSEA) data at day 360 showed that WTC dust could potentially impact the myocardial energy metabolism via PPAR signaling and heart valve development. This is the first study showing that WTC dust could significantly affect some genes that are associated with the heart/CV system, in the long term. Even > 20 years after the 9/11 disaster, this has potentially important implications for those FR exposed repeatedly at Ground Zero over the first week after the buildings collapsed. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Dust Emergency Responders Laboratories Occupational Health Respiratory System Safety September 11 Terrorist Attacks
• Keywords:
  Author Keywords: WTC Dust Cardiac Function Cardiovascular Disease Dust Exposure First Responders Heart Disease Inhalation Laboratory Animals Myocardium Rat Cardiac Tissue Transcriptomic Profiles World Trade Center WTC

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• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Grant ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; Ohio ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  2
• NIOSHTIC Number:
  nn:20064420
• Citation:
  Int J Environ Res Public Health 2022 Jan; 19(2):919
• Contact Point Address:
  Sung-Hyun Park, Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
• Email:
  SungHyun.Park@nyulangone.org
• Federal Fiscal Year:
  2022
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20090701
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20140630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8033079a9bae11bc85e3dcd3ab584aebcf28f3d7ca930c04b770709e6e0913ccf63951e09faa50db8a0cc4653031f2293a5c7157b6a50a7cc03a3e731495d23a
• Download URL:
  https://stacks.cdc.gov/view/cdc/222879/cdc_222879_DS1.pdf
• File Type:
  [PDF - 1.66 MB ]