Associations of SARS-CoV-2 Serum IgG with Occupation and Demographics of Military Personnel

Details

• Personal Author:
  Iwasaki A ; Klein J ; Liu J ; Lucas C ; Redlich CA ; Slade M ; Wisnewski AV ; Zell J
• Description:
  Background: Countries across the globe have mobilized their armed forces in response to COVID-19, placing them at increased risk for viral exposure. Humoral responses to SARS-CoV-2 among military personnel serve as biomarkers of infection and provide a basis for disease surveillance and recognition of work-related risk factors. Methods: Enzyme-linked immunosorbent assays (ELISA) were used to measure SARS-CoV-2 spike antigen-specific IgG in serum obtained from N = 988 US National Guard soldiers between April-June 2020. Occupational information, e.g. military operating specialty (MOS) codes, and demographic data were obtained via questionnaire. Plaque assays with live SARS-CoV-2 were used to assess serum neutralizing capacity for limited subjects (N = 12). Results: The SARS-CoV-2 IgG seropositivity rate among the study population was 10.3% and significantly associated with occupation and demographics. Odds ratios were highest for those working in MOS 2T-Transportation (3.6; 95% CI 0.7-18) and 92F-Fuel specialist/ ground and aircraft (6.8; 95% CI 1.5-30), as well as black race (2.2; 95% CI 1.2-4.1), household size .6 (2.5; 95% CI 1.3-4.6) and known COVID-19 exposure (2.0; 95% CI 1.2-3.3). Seropositivity tracked along major interstate highways and clustered near the international airport and the New York City border. SARS-CoV-2 spike IgG+ serum exhibited low to moderate SARS-CoV-2 neutralizing capacity with IC50s ranging from 1:15 to 1:280. In limited follow-up testing SARS-CoV-2 serum IgG levels remained elevated up to 7 months. Conclusions: The data highlight increased SARS-CoV-2 seroprevalence among National Guard vs. the local civilian population in association with transportation-related occupations and specific demographics. [Description provided by NIOSH]
• Subjects:
  Aircraft Biomarkers Communicable Diseases Demography Environmental Exposure Enzymes Men Occupational Health Race Factors Risk Assessment Risk Factors Safety Surveys And Questionnaires Transportation Viral Diseases Women

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• Keywords:
  COVID-19 Demographic Characteristics Diseases Exposure Levels Health Effects Humans Military Personnel Proteins Questionnaires Racial Factors Risk Factors Statistical Analysis Surveillance Viral Diseases Viral Infections

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• ISSN:
  1932-6203
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; Maryland ; OSHA Region 1 ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  8
• NIOSHTIC Number:
  nn:20064393
• Citation:
  PLoS One 2021 Aug; 16(8):e0251114
• Contact Point Address:
  Adam V. Wisnewski, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT
• Email:
  adam.wisnewski@yale.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  Yale University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20010701
• Source Full Name:
  PLoS One
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a7db982784a21606934f9d58e3332a2eedbf5da81fecb6332bdb7244de76ec07aff014c354a02bec1b4c25e47682c0a853b8b4cb66ea0f0a42855c5bb9efec71
• Download URL:
  https://stacks.cdc.gov/view/cdc/222858/cdc_222858_DS1.pdf
• File Type:
  [PDF - 1.19 MB ]