Modeling Neuroimmune Interactions in Human Subjects and Animal Models to Predict Subtype Specific Multidrug Treatments for Gulf War Illness (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Gulf War Illness (GWI) is a persistent chronic neuroinflammatory illness exacerbated by external stressors and characterized by fatigue, musculoskeletal pain, cognitive and neurological problems linked to underlying immunological dysfunction for which there is no known treatment. Here, we constructed a logic model of immune regulatory behavior between human clinical samples and mouse models of GWI subtyped by exposure to traumatic stress. We identify several ideal multi-intervention strategies and potential drug candidates that may be used to treat chronic neuroinflammation in GWI. [Description provided by NIOSH]
• Subjects:
  Chronic Disease Drug Therapy Fatigue Immune System Nervous System Nervous System Diseases Occupational Health Safety Stress Disorders, Post-Traumatic
• Keywords:
  Chronic Diseases Cognitive Function Drug Therapy Immune Reaction Intervention Military Personnel Neurological Disorders Neurophysiological Effects Traumatic Incident Stress
• DOI:
  https://doi.org/10.26616/NIOSHRD-1028-2021-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20064244
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1028-2021-0, 2021 Dec; :dataset
• Contact Point Address:
  NIOSH/HELD Toxicology and Molecular Biology Branch, Phone: (304) 285-6272
• Federal Fiscal Year:
  2022
• Peer Reviewed:
  False
• Source Full Name:
  Modeling neuroimmune interactions in human subjects and animal models to predict subtype specific multidrug treatments for Gulf War Illness
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6a3fbcd07700abf8e9a418eb042fb159a9f1660bd31ddcc2834c5d83b3c45cfa7eafee9f09e6c7ecd20755e2ebdef1ad64e79e7523fa723608b00c05c2a3fae1
• Download URL:
  https://stacks.cdc.gov/view/cdc/222743/cdc_222743_DS1.pdf
• File Type:
  [PDF - 268.28 KB ]