Nanoparticle Generation and Size Characterization

Details

• Personal Author:
  Hammad Y ; Marty A
• Description:
  Objective: The generation of nanoparticles is a necessary component for determining health outcomes as they relate to exposure in animal models. Unfortunately, a bulk nanopowder cannot simply be aerosolized into nano-sized particles due to the agglomeration that nanoparticles undergo. The objectives of this research are to generate and characterize two kinds of nanoparticles. Methods: This research attempts to generate nanoparticles using two different methods, nebulization of sodium chloride and aerosolization of aluminum oxide. Test aerosols are collected for visual inspection using electron microscopy. Samples are concurrently characterized using particle counters. Comparative data analysis of the particle counters relative to visual inspection is performed. Results: Results indicate that nebulized particles can be generated and characterized at a predetermined size. Characterization of the aerosolized aluminum oxide has been less conclusive since the output of the generator was less than predicated. Preliminary results from the visual inspection of the aerosol indicate that the aluminum oxide consists of agglomerates ranging from 130 nm to 6 um. Conclusion: The generation of particles from salt solutions is not new or novel. For the purpose of this research, it is a necessary aspect as a demonstration of our ability to characterize an aerosol. However, the generation of a nano-aerosol from a bulk nano-powder would be significant. If this method proves successful, it could offer a means to do research on the exposure, dose, and effect of nanoparticles in an animal model. [Description provided by NIOSH]
• Subjects:
  Aerosols Animals Chlorine Laboratories Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Aerosol Agglomeration Author Keywords: Nanoparticle Chlorides Dose Response Electron Microscopy Exposure Limits Generation Laboratory Animals Models Nanoparticles Nanotechnology Particle Counters Risk Factors Sampling Sodium

  More +
• Publisher:
  University of South Florida (USF)
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Florida ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  17
• NIOSHTIC Number:
  nn:20064199
• Citation:
  Sunshine ERC Research Poster Session/USF Health Research Day, February 21-23, 2013, Tampa, Florida. Tampa, FL: University of South Florida (USF), 2013 Feb; :17
• Contact Point Address:
  Adam Marty, USF Sunshine ERC, University of South Florida, College of Public Health, Dept. of Environmental & Occupational Health
• CAS Registry Number:
  Alumina (CAS RN 1344-28-1)
• Federal Fiscal Year:
  2013
• Performing Organization:
  Sunshine Education and Research Center, University of South Florida
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  SSunshine ERC Research Poster Session/USF Health Research Day, February 21-23, 2013, Tampa, Florida
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4441f4dcac55ae97e634f4b71964d3f585bbf5878963b217d5b5bf972da3412055fe5ed989083998d1e3c15ae87c29a951419c7a0e888b626bb60db650281dae
• Download URL:
  https://stacks.cdc.gov/view/cdc/222704/cdc_222704_DS1.pdf
• File Type:
  [PDF - 233.03 KB ]