An Exploratory Case-Only Analysis of Gene-Hazardous Air Pollutant Interactions and the Risk of Childhood Medulloblastoma

Details

• Personal Author:
  Bondy ML ; Lee LJ ; Lupo PJ ; Okcu MF ; Scheurer ME
• Description:
  Background: There is evidence that exposure to chlorinated solvents may be associated with childhood medulloblastoma and primitive neuroectodermal tumor (M/PNET) risk. Animal models suggest genes related to detoxification and DNA repair are important in the carcinogenicity of these pollutants; however, there have been no human studies assessing the modifying effects of these genotypes on the association between chlorinated solvents and childhood M/PNET risk. Procedure: We conducted a case-only study to evaluate census tract-level exposure to chlorinated solvents and the risk of childhood M/PNET in the context of detoxification and DNA repair genotypes. Cases (n = 98) were obtained from Texas Children's Hospital and MD Anderson Cancer Center. Key genotypes (n = 22) were selected from the Illumina Human 1M Quad SNP Chip. Exposure to chlorinated solvents (methylene chloride, perchloroethylene, trichloroethylene, and vinyl chloride) was estimated from the US EPA's 1999 Assessment System for Population Exposure Nationwide (ASPEN). Logistic regression was used to estimate the case-only odds ratios and 95% confidence intervals (CIs). Results: There were 11 significant gene-environment interactions associated with childhood M/PNET risk. However, after correcting for multiple comparisons, only the interaction between high trichloroethylene levels and OGG1 rs293795 significantly increased the risk of childhood M/PNET risk (OR = 9.24, 95% CI: 2.24, 38.24, Q = 0.04). Conclusions: This study provides an initial assessment of the interaction between ambient levels of chlorinated solvents and potentially relevant genotypes on childhood M/PNET risk. Our results are exploratory and must be validated in animal models, as well as additional human studies. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Blood Case Reports Environmental Exposure Environmental Pollution Genetics Hematologic Tests Neoplasms Nervous System Nervous System Diseases Occupational Health Safety

  More +
• Keywords:
  Air Pollutants Author Keywords: Childhood Medulloblastoma And Primitive Neuroectodermal Tumor Blood Disorders Blood Samples Cancer Case Studies Children Chlorinated Solvents Detoxification Genes DNA Repair Genes Environmental Pollution Genes Genotype Hazardous Air Pollutants Nervous System Disorders

  More +
• ISSN:
  1545-5009
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  59
• Issue:
  4
• NIOSHTIC Number:
  nn:20064125
• Citation:
  Pediatr Blood Cancer 2012 Oct; 59(4):605-610
• Contact Point Address:
  Michael E. Scheurer, PhD, MPH, Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, One Baylor Plaza, MS-BCM305 Houston, TX 77030
• Email:
  scheurer@bcm.edu
• Federal Fiscal Year:
  2013
• Performing Organization:
  University of Texas Health Science Center, Houston
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Pediatric Blood & Cancer
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3b8b7e9e7b2fc9445d09dab5f22d43b3e04b7cdecaaa58fee2f7505c5ceac81c9d2dd4fe55be01b24e7883c500c6a08c41fc5c9e3a834571c768a082e6aa9461
• Download URL:
  https://stacks.cdc.gov/view/cdc/222639/cdc_222639_DS1.pdf
• File Type:
  [PDF - 119.00 KB ]