Development and Validation of a Clinical Frailty Index for the World Trade Center General Responder Cohort

Details

• Personal Author:
  Bello GA ; Colicino E ; Crane MA ; Hung WW ; Ko FC ; Lucchini RG ; Ornstein KA ; Taioli E ; Todd AC
• Description:
  Objectives: To develop and validate a clinical frailty index to characterize aging among responders to the 9/11 World Trade Center (WTC) attacks. Methods: This study was conducted on health monitoring data on a sample of 6,197 responders. A clinical frailty index, WTC FI-Clinical, was developed according to the cumulative deficit model of frailty. The validity of the resulting index was assessed using all-cause mortality as an endpoint. Its association with various cohort characteristics was evaluated. Results: The sample's median age was 51 years. Thirty items were selected for inclusion in the index. It showed a strong correlation with age, as well as significant adjusted associations with mortality, 9/11 exposure severity, sex, race, pre-9/11 occupation, education, and smoking status. Discussion: The WTC FI-Clinical highlights effects of certain risk factors on aging within the 9/11 responder cohort. It will serve as a useful instrument for monitoring and tracking frailty within this cohort. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Cohort Studies Emergency Responders Health Care Facilities Workforce And Services Mortality Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  9/11 Responders Age Factors Author Keywords: Frailty Index Cohort Studies Emergency Responders Medical Monitoring Mortality Data Occupations Rescue Workers World Trade Center World Trade Center Cohort WTC

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• ISSN:
  0898-2643
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  Florida ; New York ; OSHA Region 2 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  33
• Issue:
  7
• NIOSHTIC Number:
  nn:20064080
• Citation:
  J Aging Health 2021 Aug-Sep; 33(7-8):531-544
• Contact Point Address:
  Ghalib A. Bello, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 17 E 102nd Street, 1 Gustave L. Levy Place, Box 1057, New York, NY 10029, USA
• Email:
  ghalibbello@gmail.com
• Federal Fiscal Year:
  2021
• Performing Organization:
  State University of New York Stony Brook
• Peer Reviewed:
  True
• Start Date:
  20040715
• Source Full Name:
  Journal of Aging and Health
• End Date:
  20110630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:227dcba61ef7b4d44b2e730ac5fbffeec21d601b97da76a8786945bf6c42ca1aea05670028ce8fb701e8f9b091365747608521296c153e1d44bfb301422134b3
• Download URL:
  https://stacks.cdc.gov/view/cdc/222606/cdc_222606_DS1.pdf
• File Type:
  [PDF - 878.52 KB ]