Predictors of Kidney Disease Progression in Diabetes and Precision Medicine: Something Old, Something New, and Something Borrowed

Details

• Personal Author:
  Coca SG ; Vasquez-Rios G
• Description:
  Diabetes mellitus is the leading cause of ESKD worldwide. The last few years have seen an explosion of evidence for the efficacy of sodium-glucose transporter type 2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists, and mineralocorticoid receptor antagonists to slow progression of diabetic kidney disease (DKD). However, timely guideline-based treatment of DKD at treatable stages before irreversible fibrosis is rampant is woefully inadequate. In fact, a recent study demonstrated that >10 % of patients with diabetes and DKD are treated with SGLT2i, despite the plethora of data that show their renal and cardiovascular protection in this population. Can better ascertainment of various pathophysiologic processes in DKD-a complex syndrome with varying degrees of cellular stress, metabolic imbalance, and tubulion-terstitial fibrosis-ultimately enable better identification of patients that will experience progression of DKD and allow for more efficient and effective clinical care? [Description provided by NIOSH]
• Subjects:
  Blood Fibrosis Hematologic Diseases Occupational Health Safety
• Keywords:
  Blood Sugar Disorders Cardiovascular Function Health Effects Kidney Disorders Kidneys
• ISSN:
  1046-6673
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  32
• Issue:
  9
• NIOSHTIC Number:
  nn:20063934
• Citation:
  J Am Soc Nephrol 2021 Sep; 32(9):2108-2111
• Contact Point Address:
  Dr. Steven G. Coca, Division of Nephrology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1243, New York, NY 10029
• Email:
  steven.coca@mssm.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  False
• Start Date:
  20170701
• Source Full Name:
  Journal of the American Society of Nephrology
• End Date:
  20200630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:211d4eaae38aaef53272c3d5bad24212a5add891cbc18c606a41bb518e818f79fcaba9e04316e9b207981827368b7c36db7cfb4880f30e97036edc636710c40a
• Download URL:
  https://stacks.cdc.gov/view/cdc/222468/cdc_222468_DS1.pdf
• File Type:
  [PDF - 1.07 MB ]