The Beta-Adrenergic Receptor Blocker and Anti-Inflammatory Drug Propranolol Mitigates Brain Cytokine Expression in a Long-Term Model of Gulf War Illness (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Growing evidence suggests that Gulf War Illness (GWI) is the result of underlying neuroimmune dysfunction. For example, previously we found that several Gulf War-relevant organophosphate, acetylcholinesterase inhibitors produce heightened neuroinflammatory responses following a subchronic stressor exposure. The goal of the study was to evaluate the potential for the beta-adrenergic receptor inhibitor and anti-inflammatory drug, propranolol, to treat neuroinflammation in a novel long-term mouse model of GWI. We established that our long-term GWI model produces enhanced and prolonged neuroinflammation that is dependent upon Gulf War-relevant organophosphate exposure. Propranolol treatment abrogated the neuroinflammation instigated in our model specifically, having no treatment effects in non-DFP exposed groups. Our results indicate that propranolol may be a promising therapy for GWI by treating the underlying neuroinflammation associated with Gulf War-relevant physiological stress and organophosphate exposures. [Description provided by NIOSH]
• Subjects:
  Animals Immune System Nervous System Nervous System Diseases Occupational Health Safety
• Keywords:
  Animal Studies Cytokines Immune Reaction Military Personnel Neurological Disorders Physiological Stress Sarin
• DOI:
  https://doi.org/10.26616/NIOSHRD-1024-2021-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20063887
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1024-2021-0, 2021 Nov; :dataset
• Contact Point Address:
  Toxicology and Molecular Biology Branch, Health Effects Lab Division, National Institute for Occupational Safety and Health, Morgantown, WV, (304) 285-6272
• CAS Registry Number:
  Propranolol (CAS RN 525-66-6)
• Federal Fiscal Year:
  2022
• Peer Reviewed:
  False
• Source Full Name:
  The beta-adrenergic receptor blocker and anti-inflammatory drug propranolol mitigates brain cytokine expression in a long-term model of Gulf War Illness
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:19234c296d64344f4bf511ef11339b6ad1fdb34069f2caeca0e5cf5517425fd8a03292d39dadc5f4bcb4148cf56c89f90219aedec67a8f32a061a77fc38f35d7
• Download URL:
  https://stacks.cdc.gov/view/cdc/222427/cdc_222427_DS1.pdf
• File Type:
  [PDF - 157.18 KB ]