Cutaneous Microvascular Vasodilatory Consequences of Acute Consumption of a Caffeinated Soft Drink Sweetened with High-Fructose Corn Syrup

Details

• Personal Author:
  Baker TB ; Carter SJ ; Freemas JA ; Greenshields JT ; Johnson BD ; Keeler JM ; Schlader ZJ
• Description:
  This study tested the hypotheses that compared to drinking water, consumption of a caffeinated soft drink sweetened with high-fructose corn syrup (HFCS) attenuates the cutaneous vasodilatory response to local skin heating without (Protocol 1) and following ischemia-reperfusion injury (Protocol 2). In a randomized, counterbalanced crossover design, 14 healthy adults (25 +/- 3 year, 6 women) consumed 500 ml of water (water) or a caffeinated soft drink sweetened with HFCS (Mtn. Dew, DEW). Thirty minutes following beverage consumption local skin heating commenced on the right forearm (Protocol 1), while on the left forearm ischemia-reperfusion commenced with 20 min of ischemia followed by 20 min of reperfusion and then local skin heating (Protocol 2). Local skin heating involved 40 min of heating to 39 degree C followed by 20 min of heating to 44 degree C. Skin blood flow (SkBf, laser Doppler) data were normalized to mean arterial pressure and are presented as a cutaneous vascular conductance (CVC) and as percentage of the CVC response during heating to 44 degree C (%CVCmax ). Protocol 1: During local heating at 39 degree C, no differences were observed in CVC (water: 2.0 +/- 0.6 PU/mmHg; DEW: 2.0 +/- 0.8 PU/mmHg, p = 0.83) or %CVCmax (water: 59 +/- 14%; DEW 60 +/- 15%, p = 0.84) between trials. Protocol 2: During local skin heating at 39 degree C, no differences were observed in CVC (water: 1.7 +/- 0.5 PU/mmHg; DEW: 1.5 +/- 0.5 PU/mmHg, p = 0.33) or %CVCmax (water: 64 +/- 15%; DEW 61 +/- 15% p = 0.62) between trials. The cutaneous microvascular vasodilator response to local heating with or without prior ischemia-reperfusion injury is not affected by acute consumption of a caffeinated soft drink sweetened with HFCS. [Description provided by NIOSH]
• Subjects:
  Blood Hot Temperature Men Occupational Health Safety Skin Women
• Keywords:
  Author Keywords: High-fructose Corn Syrup Caffeine Heat Humans Injuries Ischemia-reperfusion Injury Local Skin Heating Microvasculature Soft Drink
• ISSN:
  2051-817X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  9
• Issue:
  20
• NIOSHTIC Number:
  nn:20063839
• Citation:
  Physiol Rep 2021 Oct; 9(20):e15074
• Contact Point Address:
  Zachary J. Schlader, H.H. Morris Human Performance Laboratories, Department of Kinesiology, School of Public Health, Indiana University, Bloomington, IN
• Email:
  zschlade@indiana.edu
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Agriculture, Forestry and Fishing ; Construction
• Performing Organization:
  Indiana University, Bloomington
• Peer Reviewed:
  True
• Start Date:
  20190901
• Source Full Name:
  Physiological Reports
• End Date:
  20240831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:46be992e8fd2eae41fb8bcdf7326c41254f0bf8c8737ebe74cfce276452fae4de12c1ca3da67c48add06eb4f23f5f2cdb181d3fc7c4433d2d44d6a4c38d00294
• Download URL:
  https://stacks.cdc.gov/view/cdc/222386/cdc_222386_DS1.pdf
• File Type:
  [PDF - 1.18 MB ]