Cystic Fibrosis Is Associated with Adverse Neonatal Outcomes in Washington State, 1996–2013

Details

• Personal Author:
  Goss CH ; Mitchell KH ; Ramos KJ ; Sack CS ; Starr JR
• Description:
  Objective: To determine whether cystic fibrosis (CF) is associated with adverse neonatal outcomes in a recent birth cohort in the US. Study design: A retrospective matched cohort study of infants born in Washington State from 1996 to 2013 was identified through birth certificate data and linked to statewide hospital discharge data. Infants with CF were identified by hospitalization (through age 5 years) in which a CF-specific International Classification of Diseases, Ninth Revision code was recorded. "Unexposed" infants lacked CF-related International Classification of Diseases, Ninth Revision codes and were randomly selected among births, frequency-matched to "exposed" infants on birth year. Associations of CF with adverse neonatal outcomes (low birth weight [LBW], small for gestational age [SGA], preterm birth, and infant mortality) were estimated through Poisson regression. We performed extreme value imputation to address possible ascertainment bias. Results: We identified 170 infants with CF and 3400 unexposed infants. CF was associated with increased relative risk (95% CI) of 3.5 (2.5-4.9), 1.6 (1.1-2.4), 3.0 (2.2-4.0), and 6.8 (1.7-26.5) for LBW, SGA, preterm birth, and infant death, respectively. The estimated relative risks were similar among infants born from 2006 to 2013, except SGA was no longer associated with CF diagnosis. Results were robust to extreme value imputation and exclusion of infants with meconium ileus. Conclusions: Observed associations of CF with LBW, preterm birth, and infant death are unlikely to be due to ascertainment bias. Further work is needed to determine how to prevent these adverse neonatal outcomes. [Description provided by NIOSH]
• Subjects:
  Body Weight Cohort Studies Fetus Fibrosis Lung Diseases Mortality Occupational Health Pregnancy Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Low Birth Weight Body Weight Cohort Studies Genetic Disorders Infant Mortality Lung Disease Mortality Rates Prematurity Preterm Birth Small For Gestational Age
• ISSN:
  0022-3476
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  180
• NIOSHTIC Number:
  nn:20063800
• Citation:
  J Pediatr 2017 Jan; 180:206-211.e1
• Contact Point Address:
  Kathleen J. Ramos MD, Division of Pulmonary and Critical Care Medicine, University of Washington Medical Center, Box 356522 1959 NE Pacific St, Seattle, WA 98195
• Email:
  ramoskj@uw.edu
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  The Journal of Pediatrics
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2604cf2023aff3bf73abf603f11f8b8ad3384bc92bf726f77357ac4e0eae382859897e2f89c34524b0f3547d03af6a31d613f5b9f0df47f17ad1d275a14f46f4
• Download URL:
  https://stacks.cdc.gov/view/cdc/222353/cdc_222353_DS1.pdf
• File Type:
  [PDF - 205.98 KB ]