Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Meyer, Benjamin ; Müller, Marcel A. ; Corman, Victor M. ; Reusken, Chantal B.E.M. ; Ritz, Daniel ; ... More +
Meyer, Benjamin ; Müller, Marcel A. ; Corman, Victor M. ; Reusken, Chantal B.E.M. ; Ritz, Daniel ; Godeke, Gert-Jan ; Lattwein, Erik ; Kallies, Stephan ; Siemens, Artem ; van Beek, Janko ; Drexler, Jan F. ; Muth, Doreen ; Bosch, Berend-Jan ; Wernery, Ulrich ; Koopmans, Marion P.G. ; Wernery, Renate ; Drosten, Christian ; Less -
Description:
Middle East respiratory syndrome coronavirus (MERS-CoV) has caused an ongoing outbreak of severe acute respiratory tract infection in humans in the Arabian Peninsula since 2012. Dromedary camels have been implicated as possible viral reservoirs. We used serologic assays to analyze 651 dromedary camel serum samples from the United Arab Emirates; 151 of 651 samples were obtained in 2003, well before onset of the current epidemic, and 500 serum samples were obtained in 2013. Recombinant spike protein-specific immunofluorescence and virus neutralization tests enabled clear discrimination between MERS-CoV and bovine CoV infections. Most (632/651, 97.1%) camels had antibodies against MERS-CoV. This result included all 151 serum samples obtained in 2003. Most (389/651, 59.8%) serum samples had MERS-CoV-neutralizing antibody titers >1,280. Dromedary camels from the United Arab Emirates were infected at high rates with MERS-CoV or a closely related, probably conspecific, virus long before the first human MERS cases.
Subject:
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Animals
Antibodies, Neutralizing
Antibodies, Viral
Camelus
Coronavirus
Coronavirus Infections
Neutralization Tests
Syndrome

Source:
Emerg Infect Dis. 20(4):552-559.
Document Type:
Journal Article ;
Place as Subject:
United Arab Emirates ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:faae524d83ee098163216d9edb0082c6372391dddd68413852618287723cf230
File Type:

Supporting Files

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