Influence of Preseason Antibodies Against Influenza Virus on Risk of Influenza Infection Among Healthcare Personnel

Details

• Personal Author:
  Bessesen MT ; Cummings DAT ; Gaydos CA ; Gibert C ; Gorse GJ ; Kirpich A ; Nyquist A-C ; Perl TM ; Price CS ; Radonovich LJ Jr. ; Rattigan SM ; Rodriguez-Barradas MC ; Simberkoff MS
• Description:
  Background: The association of hemagglutination inhibition (HAI) antibodies with protection from influenza among healthcare personnel (HCP) with occupational exposure to influenza viruses has not been well-described. Methods: The Respiratory Protection Effectiveness Clinical Trial was a cluster-randomized, multi-site study that compared medical masks to N95 respirators in preventing viral respiratory infections among HCP in outpatient healthcare settings for 5,180 participant-seasons. Serum HAI antibody titers before each influenza season and influenza virus infection confirmed by polymerase chain reaction were studied over four study years. Results: In univariate models, the risk of influenza A(H3N2) and B virus infections was associated with HAI titers to each virus, study year, and site. HAI titers were strongly associated with vaccination. Within multivariate models, each log base 2 increase in titer was associated with 15%, 26% and 33-35% reductions in the hazard of influenza A(H3N2), A(H1N1) and B infections, respectively. Best models included pre-season antibody titers and study year, but not other variables. Conclusions: HAI titers were associated with protection from influenza among HCP with routine exposure to patients with respiratory illness and influenza season contributed to risk. HCP can be reassured about receiving influenza vaccination to stimulate immunity. [Description provided by NIOSH]
• Subjects:
  Antibodies Communicable Diseases Environmental Exposure Health Personnel Influenza, Human Occupational Health Personal Protective Equipment Respiratory Protective Devices Risk Assessment Risk Factors Safety Viral Diseases

  More +
• Keywords:
  Author Keywords: Influenza Virus Correlates Of Protection Exposure Levels Face Masks Health Care Personnel Hemagglutination Inhibition Antibodies Infection Prevention Influenza Models N95 Filtering Facepiece Respirators Risk Factors Vaccines Viral Diseases

  More +
• ISSN:
  0022-1899
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; District of Columbia ; Florida ; Georgia ; Maryland ; Missouri ; New York ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 6 ; OSHA Region 7 ; OSHA Region 8 ; Texas ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  225
• Issue:
  5
• NIOSHTIC Number:
  nn:20063523
• Citation:
  J Infect Dis 2022 Mar; 225(5):891-902
• Contact Point Address:
  Geoffrey J. Gorse, M.D., Division of Infectious Diseases, Allergy and Immunology Saint Louis University School of Medicine 1100 So. Grand Blvd. (DRC 8th Floor), Saint Louis, MO 63104, USA
• Email:
  gorsegj@slu.edu
• Federal Fiscal Year:
  2022
• Peer Reviewed:
  True
• Source Full Name:
  The Journal of Infectious Diseases
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0ad18af718ee07edda6e98b3919e340551fc6e7007e31c1c56d9fc22e6d41c4167c83f72b0251bc38e7ce21a5fc125a18caf90b48558c28b8cedb2552434a2be
• Download URL:
  https://stacks.cdc.gov/view/cdc/222113/cdc_222113_DS1.pdf
• File Type:
  [PDF - 877.00 KB ]