Associations Between Bone Mineral Density and Urinary Phthalate Metabolites Among Post-Menopausal Women: A Cross-Sectional Study of NHANES Data 2005–2010

Details

• Personal Author:
  DeFlorio-Barker SA ; Turyk ME
• Description:
  Bone mineral density (BMD) decreases with age, especially among post-menopausal women. Exposures to endocrine disruptors, such as phthalate diesters, could alter BMD through a variety of unidentified mechanisms. A hypothesis-generating study investigated associations between urinary phthalate metabolites and BMD at the femoral neck and spine in post-menopausal women (n = 480) participating in the National Health and Nutrition Examination Survey, from 2005 to 2010. Mono-ethyl phthalate (MEP), molar sum of low molecular weight metabolites (mono-n-butyl phthalate (MNBP), mono-isobutyl phthalate (MIBP), MEP), molar sum of estrogenic metabolites (MNBP, MIBP, MEP, mono-benzyl phthalate (MBZP)), and an estrogenic equivalency factor were negatively associated with spinal BMD. Some associations were modified by age or BMI. The cross-sectional study design, uncertainty regarding the critical time window of exposure, the potential for exposure misclassification, and residual confounding limit our abilities to draw causal conclusions regarding phthalate metabolites and BMD in post-menopausal women. Future studies should address these limitations. [Description provided by NIOSH]
• Subjects:
  Endocrine System Occupational Health Phthalic Acids Safety Women
• Keywords:
  Author Keywords: Urinary Phthalates Bone Disorders Bone Mineral Density Cross Sectional Studies Endocrine Disrupters Endocrine Disruptors Estrogenic Hormones National Health And Nutrition Examination Survey Phthalates Skeletal System
• ISSN:
  0960-3123
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  326-345
• Volume:
  26
• Issue:
  3
• NIOSHTIC Number:
  nn:20063522
• Citation:
  Int J Environ Health Res 2016 May; 26(3):326-345
• Contact Point Address:
  Stephanie A. DeFlorio-Barker, Division of Environmental and Occupational Health Sciences, University of Illinois at Chicago School of Public Health, Chicago, IL, USA
• Email:
  sdeflor2@uic.edu
• CAS Registry Number:
  Monoethyl phthalate (CAS RN 2306-33-4)
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  International Journal of Environmental Health Research
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b76b3976f26f6606ec403e3bffc0914375c6c862f051fe79edee59927f930cfafe5ae9b42459a7a8290ece62ad4392eddd34770ccf28c5fd812d6da957fd41dd
• Download URL:
  https://stacks.cdc.gov/view/cdc/222112/cdc_222112_DS1.pdf
• File Type:
  [PDF - 547.10 KB ]