Joint Analysis of Current Status and Marker Data: An Extension of a Bivariate Threshold Model

Details

• Personal Author:
  He X ; Lee M-LT ; Sun J ; Tong X
• Description:
  This paper considers joint analysis of current status and marker data using a threshold model based on first hitting times. A failure time is defined as the time at which a subject's latent health status process first decreases to zero. We extend the bivariate Wiener process model in Whitmore et al. (1998) to the case when only current status data are available. We develop maximum likelihood estimation procedures and provide simulation studies. We apply our methods to a motivating example involving liver tumors in mice. [Description provided by NIOSH]
• Subjects:
  Mortality Occupational Health Safety
• Keywords:
  Author Keywords: Bivariate Wiener Process Biostatistics Current Status Data First-hitting-time Model Health Status Process Joint Analysis Marker Process Mathematical Models Models Mortality Data Risk Assessment Statistical Analysis

  More +
• ISSN:
  2194-573X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Missouri ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  21
• Volume:
  4
• Issue:
  1
• NIOSHTIC Number:
  nn:20058657
• Citation:
  Int J Biostat 2008 Oct; 4(1):21
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Transportation, Warehousing and Utilities
• Performing Organization:
  University of Maryland - College Park
• Peer Reviewed:
  True
• Start Date:
  20060901
• Source Full Name:
  The International Journal of Biostatistics
• End Date:
  20090831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e60b189dbff4d9d38ba0b802552434f3fee3f72825c633502a5f369435876fd771ceececa6e98c034095368b6ae5393747e881f67e8ef767cfe1da77d7ee537d
• Download URL:
  https://stacks.cdc.gov/view/cdc/221697/cdc_221697_DS1.pdf
• File Type:
  [PDF - 250.10 KB ]